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U9. Synthesis of Nanoparticles Unit

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U9. Synthesis of Nanoparticles Unit

    • Entities: Institute of Nanoscience of Aragón (INA)
    • Address: R&D Building, Campus Río Ebro, Universidad de Zaragoza. C/Mariano Esquirl S/n, 50018, Zaragoza, Spain
    • Phone: 34 976 761000 ext. 3496
Nanabiosis-logo Universidad de Zarargoza-U9-U13-U27.
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Description

This unit, integrated in the Nanostructured Films and Particles Group at the Institute of Nanoscience of Aragón (INA) coordinated by Dr. Jesús Santamaría, has as objective the synthesis of nanoparticles with applications in biomedicine. The unit provides an automated system for the synthesis of nanoparticles using laser-induced pyrolysis of chemical precursors in gas and/or aerosol phase, which enable either individual nanoparticles or biocompatible hybrid nanostructures to be produced in large quantities. In addition, this facility is able to draw on a wide range of nanoparticles fabrication technique, as well as having the necessary specialized personnel, to undertake exhaustive characterization of the microstructure, chemical composition, particles size and distribution of sizes, as well as magnetic, optical and colloidal properties and degree of biological functionality of the synthesized material.

News U9

05 Sep

Gold nanoparticles can activate drugs inside tumors

Jesus Santamaría, Scientific Director of Unit 9 of NANBIOSIS has participated in a study that shows the ability of gold nanoparticles to generate in situ potent anticancer drugs from inert molecules thanks to a mechanism of elimination of terminal chemical groups that nanometric gold is able to catalyze. Gold is ideal for this catalytic role due to its high biocompatibility. These results, published in the journal Angewandte Chemie, offer new hope in the fight against cancer and have been obtained thanks to the collaboration of scientists of Unit 9 of NANBIOSIS and, Víctor Sebastián, Silvia Irusta and Jesús Santamaría, wit[...]

18 May

Platform2nano research by Víctor Sebastián, (Unit 9 of NANBIOSIS) awarded Marie Skłodowska-Curie

The Platform2nano research project (2012-2016) has just been awarded a second prize in the “Contribution for a better society” category, at the “Mobility Takes Research Further” conference organized by Marie Skłodowska-Curie actions (MSCA 2017) in the framework of the Presidency of Malta of the Council of the European Union. More than 195 researchers from 30 nationalities who have developed their scientific work through the prestigious Marie Skłodowska-Curie Scholarships were presented to these awards. The project “Development of a microfluidic platform to produce nanomaterials and assessment on new nanotechnology applications” in which participate the researchers Manuel Arruebo, Laura Usón, Isabel Ortiz[...]

12 May

Nanotechnology and biomedical applications. Gene therapy

Yesterday, at the University of Zaragoza, Prof. Nuria Vilaboa (CIBER-BBN– Hospital Universitario de La Paz) gave a talk  on “Nanotechnology and biomedical applications. Gene therapy“. The event was organized by Manuel Arruebo II Institute of Nanoscience of Aragon), researcher of the coordinating group of Unit 9 of NANBIOSIS. In recent years, a multitude of materials of nanometric size have been explored, which because of their small size have properties that give them a great attraction for a wide range of biomedical applications. Prof. Vilaboa reviewed gene therapy technology, where materials at  nanoscale offer interesting alternatives.[...]

20 Apr

J. Santamaría, U9 NANBIOSIS gets 2.5M € to develop a revolutionary cancer treatment

Jesús Santamaría, Scientific Director of Unit 9 of NANBIOSIS, has obtained, for the second time in six years, an ERC Advanced Grant, one of the most prestigious and extremely competitive European research grants, restricted to senior researchers with a research trajectory of high quality for more than ten years. The CADENCE (Catalytic Dual-Function Devices Against Cancer) project will be financed by the EU with 2.5M € to work for five years with a powerful team: four own researchers and seven others to be selected from candidates from all over the world. With this project the researchers propose a revolutionary cancer[...]

22 Mar

Three Scientifics of NANBIOSIS in University of Zaragoza ERC 10 years celebration event

2017 is the year of the X Anniversary of the European Research Council (ERC), created to finance research projects of excellence at the frontier of knowledge of any scientific discipline. The structure of the ERC consists of an autonomous scientific council made up of 22 distinguished scientists supported by an executive agency that is responsible for implementing the program, organizing the evaluation and managing the aid. The University of Zaragoza, hosting three units of NANBIOSIS, joined the celebrations with an event that took place on March 15. Among the assistants, three Scientists of NANBIOSIS recognized with ERC: Jesús Santamaría, Scientific[...]

13 Feb

Titania-coated gold nanorods with expanded photocatalytic response

New communication in the Journal Nanoscale, from the Royal Society of Chemistry by NFP Group, coordinator of Unit 9 of NANBIOSIS. Jesús Santamaría, Scientific Director of Unit 9 of NANBIOSIS together with other authors of the Nanostructured Films and Particles (NFP) Group, coordinator of Unit 9 of NANBIOSIS, has published on February 7, 2017, a Communication in the Journal Nanoscale, from the Royal Society of Chemistry. The syntheses of materials during the research have been performed by the Platform of Production of Biomaterials and Nanoparticles of the NANBIOSIS ICTS, more specifically by the Nanoparticle Synthesis Unit, as stated in the publication. Gold[...]

17 Jan

Multifunctional biomaterials and nanomaterials
Multifunctional biomaterials and nanomaterials: the new technological revolution.

CaixaForum Zaragoza, Wednesday, January 18th, 2017 at 7:00 pm: talk by Jesús Santamaría, Scientific Director of Unit 9 of NANBIOSIS, within the Conference Cycle: Technology, the permanent revolution Nanotechnology is the application of nanoscience and, in its modern conception, implies having the ability to design nanomaterials for a specific purpose and to control the manufacturing processes that allow them to have the desired characteristics (composition, size, shape, surface characteristics). This talk presents the developments in nanotechnology as a true technological revolution. The general concepts and the influence of nanotechnology in our lives shall be discussed with examples of recent advances,[...]

24 Nov

Award to research with micronanotechnology.
Award to research with micronanotechnology.

The Royal Spanish Academy of Engineering has awarded a medal to Víctor Sebastián Cabeza, researcher of the group “Nanostructured Films and Particles”, which coordinates Unit 9 of NANBIOSIS. The prize has been awarded in recognition of his work in designing a wide variety of micro-reactors to produce nanomaterials in a controlled and successful manner, reducing time and costs, with applications in Biomedicine, catalysis or energy processes. Dr Víctor Sebastián also received the prestigious Fulbright scholarship in 2009 to carry out a postdoctoral research at the Massachusetts Institute of Technology (MIT) on nanomaterials and its development in microfluidics and in 2014[...]

U9-Synthesis of Nanoparticles Unit
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U10. Drug Formulation

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U10. Drug Formulation

  • Scientific Director: Prof. José Luis Pedraz joseluis.pedraz@ehu.es
  • Scientific Coordinator: Dr. Jesús Ciriza Astrain jeciriza@gmail.com
  • Entities: Universidad del País Vasco (UPV/EHU)
  • Address: Pharmacy & Pharmac. Technology Lab.; Facultad de Farmacia, C/Paseo de la Universidad 7, 01006 Vitoria-Gasteiz (Spain)
  • Phone: +34 945 013091
  • Fax: +34 945 013040
  • Web: NANOBIOCEL UPV/EHU
UPV-EHU
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Description

Located at the Faculty of Pharmacy, University of the Basque Country (UPV), Campus of Vitoria, is led by Prof. José Luis Pedraz and consists of large laboratories for: cell culture, chromatography equipment, sample preparation and characterization and one specific for scale preparation of pharmaceutical formulations. This Unit has the capacity to design and evaluate dosage forms both classical and new dosage forms of biotech drugs, DNA, RNA and vaccines using different methodologies based on micro and nano-medicine. The latter methodology based on the microencapsulation of cells, peptides, proteins, and in general of biotech products, as well as the development and design of non-viral vectors for gene therapy, is one of the biggest singularities of this unit. It counts with the most advanced equipment for micro and nano encapsulation.

The aim of the Unit is to determine experimentally all the variables needed to develop an optimal formulation and work instructions for preparing final pharmaceutical products.

The pharmaceutical technology applied to drug development involves the selection of materials and procedures that can be adapted to different processes that lead to specific pharmaceutical forms. To do that, the Unit counts with the most advanced equipment to cover the development for all the steps of the process.

One of the singularities of this Units is that is GLP certified by the Spanish Medicament Agency

News U10

16 May

New gelatine devices that mimic the body’s activity in bone regeneration

The NanoBioCel Group, Coordinator of Unit 10 of NANBIOSIS has led the development of new scaffolds (such as burns, trauma or tumour extractions), to regenerate critical bone defects that, in addition to physical support, offers the opportunity to release growth factors temporarily replacing the bone matrix and aiding the regeneration of bone tissue. In order [...]

18 Apr

New treatments for degenerative diseases of the retina

The final meeting of the TERET project took place last March, an initiative within the RETOS public-private collaboration initiative of the Ministry of Economy, Industry and Competitiveness funded with almost € 1 million. The project has been carried out over the past three years to develop new treatments for degenerative diseases of the retina, focusing [...]

09 Feb

bioprinted human cells
3DBio-impression systems and bio-ink for the regeneration of cartilage and bone

The Nanobiocel Group, coordinator of Unit 10 of NANBIOSIS participate in a public-private collaborative project to reach clinical application in the regeneration of osteochondral lesions, which mainly affect the knee and ankle joints. The new project is funded by the Challenges-Collaboration program of the Ministry of Economy, Industry and Competitiveness. It has a budget of [...]

18 Jan

Nanomedicine in B·Debate Fighting Blindness by Unit 10 of NANBIOSIS
Nanomedicine in B·Debate Fighting Blindness by Unit 10 of NANBIOSIS

The recent published Newsletter of Institut of Màcula and the Barcelona Màcula Foundation: Research for Vision reported about the forum  B·Debate Fighting Blindness. Future Challenges and Opportunities for Visual Restoration, September 6-7 , that gathered more than thirty experts in the different areas related with blindness. The second Session, about Nanotechnology and Nanomedicine, was chaired [...]

13 Jan

Nanbiosis U10 Micro and nano capsules that will increase the effectiveness and precision of medicine.
Micro and nano capsules that will increase the effectiveness and precision of medicine.

José Luis Pedraz, Scientific Director of Unit 10 of NANBIOSIS and members of NANOBIOCEL group, which coordinates Unit 10 of NANBIOSIS, explain for the TEKNOPOLIS program of EiTB, the first communication group in the Basque Country, the development of micro and nanocapsules, gels and scaffolds to solve the problems of administration of new drugs. The [...]

02 Dec

"It is necessary to increase our relationship with European research groups" by José Luis Pedraz - U10 of NANBIOSIS
“It is necessary to increase our relationship with European research groups” by José Luis Pedraz – U10 of NANBIOSIS

Last Sunday, November 27, the Newspaper of Álava published a special supplement with the title “ALAVA 2020”. It contained an article by José Luis Pedraz (Scientific Director of Unit 10 of NANBIOSIS) According to Dr. Pedraz, group leader of the CIBER-BBN NANOBIOCEL group, in the next future, important challenges with new technologies will allow a [...]

04 Oct

Midyear meeting in Vitoria of European project DRIVE
Midyear meeting in Vitoria of European project DRIVE

CIBER-BBN participates in the project through NanoBioCel group, led by professor José Luis Pedraz Muñoz, Scientific Director of Unit 10 of NANBIOSIS, working on the optimization of formulations to be included in a bioartificial organ. José Luis Pedraz Munoz and Jesus Izco coordinator of NANBIOSIS have participated in the meeting held in Vitoria on 3 [...]

03 Jun

Jesus Izco, Coordinator of NANBIOSIS and José Luis Pedraz, Scientific Director of Unit 10-Drug Formulation of NANBIOSIS and NanoBioCel Group of CIBER-BBN, participated in the 2ª General Assambly of DRIVE project, held in Venice, May 16th-17th 2016.
Nanbiosis in the 2ª General Assambly of DRIVE project, Venice (16th-17th 2016)

Jesus Izco, Coordinator of NANBIOSIS and José Luis Pedraz, Scientific Director of Unit 10-Drug Formulation  of NANBIOSIS and NanoBioCel Group of CIBER-BBN, participated in the 2ª General Assambly of  DRIVE project, held in Venice, May 16th-17th 2016. The second General Assembly of European project DRIVE “DIABETES-REVERSING-IMPLANTS FOR ENHANCED VIABILITY AND LONG TERM EFFICACY”, took place [...]

26 Apr

Nanbiosis_U10_Cationic nioplexes in supramolecular hydrogels as hybrid materials to deliver nucleic acids
Cationic nioplexes in supramolecular hydrogels as hybrid materials to deliver nucleic acids

Jose Luis Pedraz, Scientific Director of Unit 10 of NANBIOSIS and Ramon Eritja (CIBER-BBN) have participated in the entrapment of cationic nioplexes in supramolecular hydrogels and the use of these materials for transfecting cells. This work is focused on entrapping cationic nioplexes within supramolecular hydrogels based on N-protected phenylalanine. To modulate the supramolecular hydrogel diffusion [...]

03 Mar

Nanbiosis_Unit8-Drive Project-Improving transplant pancreatic cells_Dr. Jose Luis Pedraz
Drive Project: Improving transplant pancreatic cells

José Luis Pedraz, Scientific Director of the Unit 10: Drug Formulation of NANBIOSIS explained DRIVE European project in the third edition of Diabetes Experience Day, diabetic patients meeting that gathered 1500 people in Madrid. The DRIVE project, in which participate fourteen partners from seven European countries, among which is the CIBER-BBN, develops biomaterials and new surgical devices to improve transplantation and survival of insulin-producing pancreatic islet for the treatment diabetes.

[...]

U10-Drug Formulation
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U12. Nanostructured liquid characterization unit

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U12. Nanostructured liquid characterization unit

  • Scientific Director: Prof. Conxita Solans csmqci@cid.csic.es
  • Scientific Coordinator: Jordi Esquena jemqci@iqac.csic.es
  • Entities: Collodial and Interfacial Chemistry Group (QCI) at the Institure of Advanced Chemistry of Catalonia (ICAC) & Consejo Superior de Investigaciones Científicas (CSIC)
  • Address: Jordi Girona, 18-26, 088034, Barcelona, Span
  • Phone: +34 934 006 159
  • Web: QCI – IQAC- CSIC
IQAC CSIC
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Description

The unit is located at the Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), in Barcelona and it is coordinated by the Colloidal and Interfacial Chemistry Group, led by Dr. Concepción Solans. The unit is focused on the characterization of nanostructures in liquids and liquid/liquid interfaces, such as micelles, liposomes, micro- and nano-emulsions, and nanoparticles. The unit features state-of-the-art instrumentation for the determination of various parameters such as size distribution and zeta potential (surface charge), critical micelle concentration (CMC), solubilization capacity, osmolarity, surface and interfacial tension, wettability, refractive index, turbidity, colloidal stability, density, viscosity and other rheological parameters (shear and elastic moduli, critical yield stress, etc.)

News U12

29 May

DHA and l-carnitine loaded chitosan hydrogels as delivery systems for topical applications

The journal JCR Colloids and Surfaces A: Physicochemical and Engineering Aspects, has recently publish and interested article which show the results of the research lead by Jordi Esquena, Coordinator of Unit 12 of NANBIOSIS,. The formation of biocompatible hydrogels of chitosan crosslinked with genipine deposited on textile substrates has been studied and the incorporation and release of active ingredients for cosmetic applications has been investigated. The active principles studied have been dihydroxyacetone (DHA), which produces a sunless tanning effect; And carnitine, used as anti-cellulite agent. The results have shown that crosslinking with chitosan allows controlling the release rate of the active ingredients,[...]

24 May

Elastic and adhesion properties of adsorbed hydrophobically modified inulin films on latex particles using Atomic Force Microscopy (AFM)

In a study published in the journal Colloids and Surfaces A: Physicochemical and Engineering Aspects, by Jordi Esquena, Coordinator of Unit 12 of NANBIOSIS, among others, it has been shown that the latex particles dispersed with graft-type polymeric surfactants have excellent colloidal stability, which is attributed to the repulsion forces between the particles, which arise from the presence of adsorbed surfactant molecules. These forces of repulsion have been studied by means of Atomic Force Microscopy (AFM), between an AFM tip and a latex particle, with the presence of surfactant adsorbed on both. It has been observed that this repulsion is maintained even[...]

30 Mar

Methods for the In Vitro Characterization of Nanomedicines —Biological Component Interaction

An interesting article has been recently published, in the journal Personalized Medicine In the context of a public-private collaboration between Cristina Fornagera of Sagetis-Biotech and Conxita Solans, Scientific Director of Unit 12 of NANBIOSIS This review summarizes the main techniques used to assess the interaction of nanomedicines with biological systems, highlighting their advantages and disadvantages. The translation of knowledge from novel designed nanosystems at a research laboratory scale to real human therapies is usually a limiting or even a final point due to the lack of systematic studies regarding two aspects: nanoparticle interaction with biological components and nanoparticle cytotoxicity. For[...]

30 Mar

A new versatile methodology to produce polymeric nanoparticles loaded with gold nanoparticles

Conxita Solans, Scientific Director of Unit 12 of NANBIOSIS together with researchers of her group, Colloidal and Interfacial Chemistry of CIBER-BBN and IQAC-CSIC and the Department of Pharmacy and Pharmaceutical Technology, University of BarcelonaIn have published the research paper “Versatile Methodology to Encapsulate Gold Nanoparticles in PLGA Nanoparticles Obtained by Nano-Emulsion Templating” in the journal Pharmaceutical Research. The scientists have shown that a novel and very versatile methodology has been developed for the production of polymeric nanoparticles loaded with gold nanoparticles. In this work, gold-nanoparticles (AuNP) have been encapsulated in polymeric nanoparticles using a novel and versatile methodology based on nano-emulsion templating, whic[...]

14 Dec

From Chromonic Self-Assembly to Hollow Carbon Nanofibers: Efficient Materials in Supercapacitor and Vapor-Sensing Applications
From Chromonic Self-Assembly to Hollow Carbon Nanofibers: Efficient Materials in Supercapacitor and Vapor-Sensing Applications

Conxita Solans, Scientific Director of the Unit 12 NANBIOSIS is co-author of the research article recently published a research article in the journal Applied Materials & Interfaces. Carbon nanofibers (CNFs) with high surface area (820 m2/g) have been successfully prepared by a nanocasting approach using silica nanofibers obtained from chromonic liquid crystals as a template. CNFs with randomly oriented graphitic layers show outstanding electrochemical supercapacitance performance, exhibiting a specific capacitance of 327 F/g at a scan rate of 5 mV/s with a long life-cycling capability. Approximately 95% capacitance retention is observed after 1000 charge–discharge cycles. Furthermore, about 80% of capacitance is[...]

26 Oct

Water-in-water (W/W) emulsions
Water-in-water (W/W) emulsions

Jordi Esquena, Scientific Coordinator of Unit 12 of NANBIOSIS, has recently published an interesting review in the journal Current Opinion in Colloid & Interface Science, about W/W emulsions. Dr. Esquena describes the general background of research in the field and focuses on recent scientific advances and applications. Water-in-water (W/W) emulsions are colloidal dispersions of an aqueous solution into another aqueous phase. Such dispersions can be formed in mixtures of at least two hydrophilic macromolecules, which are thermodynamically incompatible in solution, generating two immiscible aqueous phases. Highly stable water-in-water emulsions can be formulated using fully biocompatible and edible components, and consequently,[...]

12 Sep

Nanbiosis-U12-Symposium honouring Professor Conxita Solans. Conference of the European Colloid and Interface Society (ECIS), Rome 2016
Symposium honouring Professor Conxita Solans. (ECIS Rome 2016)

In the frame of ECIS 2016, the 30th Conference of the European Colloid and Interface Society (ECIS), Rome 4-9 September, 2016, a special Symposium honouring Conxita Solans was organized on  September 8th – 2.00-5.00 pm. Conxita Solans, Scientific Director of Unit 12 of NANBIOSIS, has during many years been one of the leading scientists in the field of surfactants and dispersions. She has been  very active in ECIS, presenting her research results at several conferences,  being President and also organizing one ECIS meeting in Barcelona.[...]

31 Aug

DR. CONXITA SOLANS received the “Pierre Fillet” Prize 2016 awarded by the Formulation Group of the French Chemical Society (SCF)
DR. CONXITA SOLANS received the “Pierre Fillet” Prize 2016 awarded by the Formulation Group of the French Chemical Society (SCF)

Conxita Solans, Scientific Director of the Unit 12 NANBIOSIS, received last July 4 in the opening ceremony of the congress Formula VIII, the award Pierre Fillet 2016, given by the Formulation Group of the French Chemical Society (SCF). The prize was awarded to Dr Solans in recognition to her contributions on formulation of colloidal systems, namely on the design and characterization of Nanostructured Liquids such as nano-emulsions, microemulsions, micelles, etc, developed through Unit 12 of NANBIOSIS. Pierre Fillet was a major force behind formulation in France particularly and across Europe, he was one of the instigators of the first Formula[...]

U12-Nanostructured liquid characterization unit
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U15. Functional Characterization of Magnetic NPs Unit

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U15. Functional Characterization of Magnetic NPs Unit

  • Scientific Director: Prof. Francisco Del Pozo francisco.delpozo@ctb.upm.es
  • Scientific Coordinator: Jose Javier Serrano jjserran@etsit.upm.es
  • Entities: Centre for Biomedical Technology (CTB) & Universidad Politécnica de Madrid (UPM)
  • Address: Campus de Montegancedo, 28223, Pozuelo de Alarcón, Madrid, Spain
  • Phone: +34 915 495 700 ext 3322
  • Web: CTB – UPM
UPM CTB
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Description

This facility is coordinated by Dr. José Javier Serrano and Dr. Francisco del Pozo, PI of the Biomedical Engineering and Telemedicine Centre at the Centre for Biomedical Technology (CTB), Technical University of Madrid (UPM). The set-up is dedicated to the characterization of the magnetic and mechanical behavior of magnetic nanoparticles at temperatures and other environmental conditions compatible with physiological conditions. It is already possible to characterize magnetic materials (e.g., magnetic nanoparticles) in terms of their magnetic moment under applied external magnetic fields.

News U15

10 Mar

Nanbiosis U15_Secondary Proposer in COST Action European Network on NMR Relaxometry_Coord.Jose Javier Serrano
Jose Javier Serrano, coordinator of Unit 15 of NANBIOSIS: Secondary Proposer in COST Action European Network on NMR Relaxometry

The “European Network on NMR Relaxometry” Action aims to develop a research network focused on NMR relaxometry for fundamental and applied sciences concerned with the molecular dynamics of soft and hard matter. NMR relaxometry possesses the unique ability to reveal the mechanisms of molecular motion and their characteristic times over a huge range of time scales from picosecond to millisecond, with selectivity in probing the dynamics of molecular and ionic species. This potential of NMR relaxometry will be developed with applications in advanced materials science and industry, medical diagnostics and therapeutics, agri-food and environmental science and technologies. This research is[...]

U15-Functional Characterization of Magnetic NPs Unit
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