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NANBIOSIS Unit 27 at VPH2018: VIRTUAL PHYSIOLOGICAL HUMAN 2018

The VPH Conference 2018 is taking place in Zaragoza 5-7 September offering an exciting program of state-of-the art science & engineering in computational (bio)medicine, ranging from foundational research on multiscale modelling of human (patho) physiology, via underpinning research on data science and infrastructures for the virtual physiological human, to clinical applications with participation of NANBIOSIS U27. High Performance Computing

Esther Pueyo  is charing the Session 3A: Cardiovascular modeling: from simulation to clinical outcome,

Some of the outcomes are presented by Jesús Fernández-Bes:

A Bayesian Filtering methodology to identify key drivers of ventricular repolarization variability (Jesus Fernandez-Bes, David Adolfo Sampedro-Puente and Esther Pueyo) 

Virtual Physiological Human (VPH), refers to the field of integrative mathematical modelling and simulations in the study of human biology and physiology. VPH is a methodological and technological framework to share observations, to derive predictive hypotheses from possible aspects of human physiology or pathology, and to integrate them into a constantly improving understanding of human physiology and pathology, by regarding it as a single system. Currently, the VPH is a worldwide effort to develop next-generation computer technologies to integrate all information available, from genetics to medical images to clinical data for each patient, and generate computer models capable of predicting how the health of that patient will evolve under certain conditions. The VPH is now a well-established worldwide community, with the VPH institute representing it.

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Nanoplasmonic biosensor device for the monitoring of acenocoumarol therapeutic drug in plasma

As a result of the collaboration carried aout by two units of NANBIOSIS, U4. Biodeposition and Biodetection Unit and U2. Custom Antibody Service (CAbS), it has been developed a compact and simple nanoplasmonic sensing device based on gold nanodisks for the rapid monitoring of acenocoumarol, using highly specific polyclonal antibodies produced against the drug Acenocoumarol (Sintrom®) which implies:

  • A label-free nanoplasmonic device for the rapid monitoring of acenocoumarol in plasmaD.
  • Direct quantification in real time requiring low sample volume is achieved.
  • Non-specific interferences from plasma are minimized using the developed methodology.
  • Excellent accuracy has been observed measuring blind plasma samples.
  • Potential to be implemented as a POC device in decentralized settings.

 

The research details have been published in the article authored by E. CristinaPeláez, M.-CarmenEstevez, AlejandroPortela, J.-PabloSalvador, M.-PilarMarco and Laura M.Lechuga, “Nanoplasmonic biosensor device for the monitoring of acenocoumarol therapeutic drug in plasma, Biosensors and Bioelectronic, 119, 2018, 149-155 – DOI: https://doi.org/10.1016/j.bios.2018.08.011

 

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COURSE FOR THE PERFORMANCE OF FUNCTIONS A, B AND C IN RODENTS, LAGOMORFOS, CARNIVORES, PIGS AND SMALL RUMINANTS

On November 2th-30th, Centro de Cirugía de Mínima Invasión Jesús Usón, partner of NANBIOSIS, organizes a theorical and practical course:  “Course for the performance of functions a, b and c in rodents, lagomorfos, carnivores, pigs and small ruminants”. Some researchers of NANBIOSIS Units at JUMISC, will transmit their knowhow and experience to the attendees.

The course objetives are to provide adequate training to researchers in the science and welfare of the laboratory animal, as well as the use of bloodless methods of euthanasia that will be carried out with experimental animals in accordance with current legislation and existing recommendations.

This course, once met all the requirements demanded by the Competent Authority (supervised work period) by the students, will provide accreditation for the performance of FUNCTIONS A (care of animals), B (euthanasia of animals) and C (realization of procedures), granted by the Ministry of Environment and Rural, Agrarian Policies and Territory. These functions correspond to those established in article 15, point 2 letters a), b) and c) of Royal Decree 53/2013, of February 1, which establishes the basic rules applicable for the protection of animals used in experimentation and other scientific purposes, including teaching

Program

Inscription

 

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Recombinant proteins production: optimization strategies.

On October 24th-26th, Aula Científica, in collaboration with IBB, organizes a theorical and practical course on “Recombinant proteins production: optimization strategies“. Some researchers of NANBIOSIS Unit1 Protein Production Platform (PPP), will transmit their knowhow and experience to the attendees, as José Luis Corchero, Rosa Mendoza Moreno and Neus Ferrer Miralles, Scientific Director of the Protein production planform of ICTS NANBIOSIS.

The course is aimed at researchers and laboratory technicians from universities, hospitals, companies and research centers who are interested in the expression, production and purification of recombinant proteins with de objectives of analyze and design strategies for the improvement in the expression, production and purification of recombinant proteins in heterologous systems.

Information and registration:

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Conversion of Biomolecules into pharmaceuticas Leads using nanovesicles

Nathaly Segovia, Scientific coordinator of NANBIOSIS U 6, Biomaterial Processing and naostructuring unit, explains in this video what the objective of her unit , the services they offer and their technologies  in the field of drug delivery.

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Peptides, targeting units and drug conjugates

Miriam Royo, Scientific Coordinator of Unit 3 of NANBIOSIS explains in this video the expertise of the unit in the preparation of difficult peptides (Cyclid and polycyclic peptides, stapled peptides and dificult peptides, depsipetides, natural products and libraries, peptidomimetic libraries, peptides as antigens or adjuvants, tarjeted drug conjugates, etc… as well as therapeutic agen-PEG-targeting unit conjugates

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Advanced methods of continuous production of Nanomaterials

Victor Sebastian, researcher of  NANBIOSIS Unit 9 Synthesis of Nanoparticles Unit, explains the production technologies in continuous (Microfluidic systems liquid phase or pyrolysis activated by laser, gas phase in which the nanoparticles are produced)

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Micro and nanotechnologies for the release of biotechnological products

José Luis Pedraz, Scientific Director of NANBIOSIS Unit 10, Drug formulation, talks in this video about Micro and polymeric nanoparticles, lipid nanoparticles, non-viral vectors for gene therapy and scaffolds for cell therapy and regenerative medicine and bio 3D printing

 

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Formulation and characterization of pharmaceutical products

Jordi Esquena, Coordinador científico de la Unidad 12 de NANBIOSIS Nanostructured liquid characterization unit taks about the Autoagregation to surfactant systems

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Nanoparticle uptake and in vivo estimates of therapeutic efect and toxicity

Ramón Mangues, Scientific Dierctor of unit 18 of NANBIOSIS, Unit of nanotoxicology, explains in this video some of the animal models used in the unit for preclinical validation of nanoparticles, especially of application in cancer

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