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Nanbiosis

U12. Nanostructured liquid characterization unit

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U12. Nanostructured liquid characterization unit

    • Scientific Director: Prof. Carlos Rodríguez cranqb@cid.csic.es
    • Scientific Coordinator: Jordi Esquena jemqci@iqac.csic.es
    • Entities: Colloid and Interfacial Chemistry Group (QCI) at the Institute of Advanced Chemistry of Catalonia (IQAC) & Consejo Superior de Investigaciones Científicas (CSIC)
    • Address: Jordi Girona, 18-26, 088034, Barcelona, Spain
    • Phone: +34 934 006 159
    • Web: QCI – IQAC- CSIC


IQAC CSIC

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Description

The unit is located at the Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), in Barcelona and it is coordinated by the Colloidal and Interfacial Chemistry Group, led by Dr. Carlos Rodríguez. The unit is focused on the characterization of nanostructures in liquids and liquid/liquid interfaces, such as micelles, liposomes, micro- and nano-emulsions, and nanoparticles. The unit features state-of-the-art instrumentation for the determination of various parameters such as size distribution and zeta potential (surface charge), critical micelle concentration (CMC), solubilization capacity, osmolarity, surface and interfacial tension, wettability, refractive index, turbidity, colloidal stability, density, viscosity and other rheological parameters (shear and elastic moduli, critical yield stress, etc.)

The Unit 12 has implemented and mantein the ISO9001 certification for standard quality control system.

IQNet ISO 9001:2015 Certification 

AENOR ISO 9001:2015 Certification 

U12. Services & Rates

Active projects

Title Fundin: Organism Call: Funding source Role
SAF2017-90810-REDI Strategic Promotion and coordinated management of Nanbiosis: Pronanbiosis II Agencia Estatal de Investigación (AEI) Acciones de dinamización «REDES DE EXCELENCIA» -ICTS 2017 Partner
PICCOLO-732111 Multimodal highly-sensitive PhotonICs endoscope for improve in vivo COLOn Cancer diagnosis and clinical decision support European Commission-H2020 H2020-ICT-2016-1 Partner
0624_2IQBIONEURO_6_E Promotion of an R&I network in biological chemistry for the diagnosis and treatment of neurological diseases European Union Interreg : European Territorial Co-operation POCTEP Interreg España-Portugal Partner

Other projects

Ref Title Funding Organism Unit Role
CTQ2014-52687-C3-1-P Design and applications of new biocompatible micro / nanogels obtained by advanced condensation methods (MICRONANOGELES) MINECO Participant
2014SGR1655 Grants for consolidated Research Groups of Catalonia Generalitat de Catalunya Participant
FP7-PEOPLE-2013-ITN - 606713 Biopolymer Based FOOd Delivery Systems (BIBAFOODS) Unión Europea Participant
Plan de Actuación 2015 Agreement of ACC1Ó with the UAB, the PRUAB, the CSIC and the CVC for the promotion of the technological transfer Generalitat de Catalunya Participant
TECSPR14-2-0033 Theranostic Magnetic Nanoparticles For Cancer Diagnosis and Treatment: Magnetic Properties and Controlled Release of Anticancer Drugs (TheraMagNano) Unión Europea Participant
TECSPR14-2-0044 Novel antimicrobial hydrogels for contact lenses (HYDROLENSES) Unión Europea Participant
Acción COST CM1101 Joint Meeting of WG 3 and WG 4. Workshop "Nano-biocolloidal materials and non-equilibrium self-assembly" Unión europea Participant
Ref.: 308810 076/2015 DEVELOPMENT OF INNOVATIVE FORMULATIONS FOR THE DELIVERY OF ACTIVITIES INTO THE SKIN (ES) ALMIRALL Participant

Publications

2016

  • Fornaguera C., Caldero G., Solans C.. Electrolytes as a tuning parameter to control nano-emulsion and nanoparticle size. RSC Advances. 2016;6(63):58203-58211.
  • Caldero G., Montes R., Llinas M., Garcia-Celma M.J., Porras M., Solans C.. Studies on the formation of polymeric nano-emulsions obtained via low-energy emulsification and their use as templates for drug delivery nanoparticle dispersions. Colloids and Surfaces B: Biointerfaces. 2016;145:922-931.
  • Fornaguera C., Feiner-Gracia N., Caldero G., Garcia-Celma M.J., Solans C.. PLGA nanoparticles from nano-emulsion templating as imaging agents: Versatile technology to obtain nanoparticles loaded with fluorescent dyes. Colloids and Surfaces B: Biointerfaces. 2016;147:201-209.
  • Magana J.R., Kolen’Ko Y.V., Deepak F.L., Solans C., Shrestha R.G., Hill J.P. et al. From Chromonic Self-Assembly to Hollow Carbon Nanofibers: Efficient Materials in Supercapacitor and Vapor-Sensing Applications. ACS Applied Materials and Interfaces. 2016;8(45):31231-31238.
  • Perez-Carrillo L.A., Vilchez S., Mosa J., Aparicio M., Castro Y., Duran A. et al. Synthesis and properties of TiO2-P2O5 and SiO2-TiO2-P2O5 porous hybrids obtained by templating in highly concentrated emulsions. Ceramics International. 2016;42(16):18965-18973.

News U12

08 Mar

The revolutionary path of research in NANBIOSIS and advice on Woman’s Day 2024

Our interview series delve into the journeys of 7 female researchers, their challenges, and the call for gender equality in science, inspiring the next generation. March 8th 2024, NANBIOSIS (Spain) Kicking off on 11F “International Day of Women and Girls in Science” 2024, and spanning all the way until Woman’s Day 2024, our interview series has aimed to highlight the life, career and opinions of some of the brilliant minds within our network. Today is time to wrap it up, and for this reason we present you a summary of each of them and a chance to take a deeper[...]

01 Mar

Women in NANBIOSIS part 5: Susana Vílchez and her insights on water-in-water emulsions and gender equality in Science

Dr. Vílchez, our esteemed colloidal chemistry researcher, discusses her focus on water-in-water emulsions and microcoacervates. She highlights gender biases in science and advocates for inclusivity and recognition of women’s contributions. This is part of a series of interviews to several female researchers within the context of International Day of Women and Girls in Science 2024 and Woman’s Day 2024. For more interviews, visit our news section here. March 2024, IQAC-CSIC, Barcelona (Spain) Dr. Susana Vílchez, an esteemed researcher in colloidal chemistry, and the technical and quality manager of Unit 12 of NANBIOSIS, offers a profound insight into her research endeavors[...]

06 Feb

‘Magic Bullets’ Against Cancer: Unveiling the Potential of DNA Nanoparticles

DNA nanoparticles to selectively target tumor tissues through precise control of the synergies between transported drugs. February 2024, IQAC-CSIC/CIBER-BBN, Barcelona. The team led by Drs. Carme Fàbrega and Ramón Eritja, in close collaboration with 3 units of the NANBIOSIS ICTS, has developed a new strategy to improve the efficacy and reduce the toxicity of anticancer drugs. They have chemically linked several cytotoxic drugs, currently used in the treatment of various types of tumors, to DNA nanostructures. These structures selectively target cancerous tissues through folate receptors. This tactic allows precise control of drug concentration and exploits their combined effect. The results[...]

25 Sep

Carlos Rodriguez-Abreu (NANBIOSIS U12) keynote speaker at the European Colloid and Interface Society ECIS 2023

Carlos Rodriguez-Abreu, Scientific Director of NANBIOSIS U12 Nanostructured liquid characterization unit  gave a Keynote presentation entitled “Chromonic liquid crystal emulsions” at the European Colloid and Interface Society ECIS 2023 conference held in Naples, Italy (September 3-8, 2023) . Chromonic liquid crystals (CLC) can be used as templates for material synthesis and, since some CLC are nontoxic and water-based, they are also interesting for biological and medical applications. The presentation included a summary of experimental results on internally structured emulsions made of CLC encapsulated in droplets, that feature various complex morphologies. Photothermal, sensing and imaging applications are envisaged.[...]

15 Nov

Happy Day of Chemistry! The role of Chemistry in a sustainable research in health

Today, November 15 is a day of celebration for us, the Day of the Chemistry in Spain! Chemistry is the science that studies matter, how it is composed, its properties and how its structures are transformed and, as matter is everything, including living beings and ourselves, we can say that chemistry is omnipresent and transversal in all areas surrounding us. Chemistry is everywhere, we ourselves are chemistry and our health and our life is chemistry. “Everything around us is chemistry in the environment, foods, what we use and what we touch every day. Our own body is a sophisticated complex[...]

27 Jul

1st Nanomedicine Forum of CIBER-BBN/NANBIOSIS and CSIC Nanomed Conection

During the days 30 of June and 1st of July took place in Barcelona, in the auditorium of the Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), the 1st Forum on Nanomedicine gathering scientists from the CSIC net Nanomed Conection and from the CIBER-BBN and its ICTS NANBIOSIS. This forum brought toguether researchers from the most eminent national research centers in nanomedicine, that during the two days meeting presented their works and findings and discussed the impact of nanomedicine in the fields of drug delivery, diagnosis and therapy. The workshop was open by the Director of IQAC-CSIC,  Jesús Joglar, the  Scientific Coordinator[...]

03 May

OPEN SUBMISSION FOR JOURNAL SPECIAL ISSUE ON OLIGONUCLEOTIDE BASED THERAPIES

Dr. Ramon Eritja, Scientific Director of NANBIOSIS unit 29 of Oligonucleotide Synthesis Platform (OSP) and Dr. Santiago Grijalvo researcher at NANBIOSIS unit 12 of Nanostructured liquid characterization, from CIBER-BBN and IQAC-CSIC, together with Dr. Andreia F. Jorge, from Coimbra Chemistry Centre (CQC), acting as guest editors of journal Pharmaceutics, of MDPI Publisher, welcome authors to submit their articles on special issues on Recent Trends in Oligonucleotide Based Therapies. In the past few decades, significant efforts have been made towards the clinical application of oligonucleotides. However, the potential of the therapeutic applications of RNA-based strategies have recently been spotlighted after the first approval of mRNA vaccines in response to COVID-19[...]

02 May

Wide representation of NANBIOSIS research in NALS 2022 and best Oral Presentation to Eloi Parladé

During the last 27-29 April, the 3rd International Conference on Nanomaterials Applied to Life Sciences 2022 (NALS 2022) has taken place in the Excellence Campus of Universidad de Cantabria in Santander (Spain), organized by the University of Cantabria and Institute Valdecilla-IDIVAL. NALS 2022 has been a multidisciplinary conference series sharing new results and ideas in the fields of biosensors, lab on a chip, drug delivery nanopharmacy. nanobiotechnology, intelligent nanomaterials, magnetic materials, nanotoxicity, antimicrobials, novel applications of 3d bioprinting and nanoimaging. NANBIOSIS has been represented at this edition by members of several of its units, among them we must highlight the set of four ora[...]

U12-Nanostructured liquid characterization unit
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U13. Tissue & Scaffold Characterization Unit

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U13. Tissue & Scaffold Characterization Unit

  • Scientific Director: Prof. Miguel Angel Martínez miguelam@unizar.es
  • Scientific Coordinator: Fany Peña fany@unizar.es
  • Entities: Universidad de Zaragoza. Departamento de Ingeniería Mecánica.
  • Address: Campus Río Ebro. Edificio I D I. C/ María de Luna, S/N, 50018 Zaragoza, Spain
  • Phone: 34 976 761 000 ext 5233 / 34 976 761 912
  • Web: I3A-UZ

Nanabiosis-logo Universidad de Zarargoza-U9-U13-U27.
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Description

This platform is coordinated by Dr. E. Peña member of the Applied Mechanics and Bioengineering Group of the Aragón Institute of Engineering Research (I3A) at the University of Zaragoza. The objective of this unit is to provide services for structural and physical characterization of biological tissues and tissue scaffolding, including microstructure, histology and mechanical tests among others. This platform, unique in Spain as regarding its capability, has a clear and direct translational impact, especially in regenerative medicine, implant design and evaluation, as well as in the study of the mechanical behavior of living tissues (especially in the musculoskeletal and cardiovascular systems). Its relationship with the Instituto Aragonés de Ciencias de la Salud (Health Sciences Institute of Aragon), and through it with the Tissue and Blood Bank of Aragon and with the School of Veterinary Science at the Universidad de Zaragoza, allows an easy provision of tissues both from animals (mice, rabbit, sheep, pig) and humans, following in their handling the recommendations of the different ethics committees.

It has several types of INSTRON testing machines specializedin biological tissues, for the characterizationof soft tissues and fibers, as well as an X-ray microCT which allows quantitatively characterizing the microstructure of in vitro samples of hard tissues and of biomaterials for scaffolds. It also has the entire system necessary for performing high-quality histologies which would complete the structural characterization of the previously cited types of tissues (staining of preparations, immunohistochemistry in paraffin with EnVision, laser microdissection, etc.). As additional tests, equipment for determining the permeability of biological tissues and scaffolds under culture conditions, monitoring their variation over time is also available. Finally, the platform is also composed of different types of bioreactors, including perfusion or direct compression on seeded scaffolds for stimulating cell cultures for tissue engineering applications.

Active projects

Title Fundin: Organism Call: Funding source Role
SAF2017-90810-REDI Strategic Promotion and coordinated management of Nanbiosis: Pronanbiosis II Agencia Estatal de Investigación (AEI) Acciones de dinamización «REDES DE EXCELENCIA» -ICTS 2017 Partner
PICCOLO-732111 Multimodal highly-sensitive PhotonICs endoscope for improve in vivo COLOn Cancer diagnosis and clinical decision support European Commission-H2020 H2020-ICT-2016-1 Partner
0624_2IQBIONEURO_6_E Promotion of an R&I network in biological chemistry for the diagnosis and treatment of neurological diseases European Union Interreg : European Territorial Co-operation POCTEP Interreg España-Portugal Partner

Other projects

Ref Title Funding Organism Unit Role
DPI2014-54981-R CORNEAL TISSUE RESPONSE TO CROSS-LINKING TREATMENT. APPLICATION TO THE TREATMENT OF KERATOCONO MINISTERIO DE ECONOMÍA Y COMPETITIVIDAD Participant
DPI2013-44391-PReferencia DESIGN AND IMPROVEMENT OF DRUG-CAUSED INTRAVASCULAR DEVICES THROUGH A COMPUTATIONAL TOOL. APPLICATION TO THE DESIGN OF STENT AND BALLS IN STENOTIC INJURIES MINECO. MINISTERIO DE ECONOMIA Y COMPETITIVIDAD Participant
DPI2013-44987-R SMART_FOOT: SUPPORT SYSTEM FOR PREOPERATIVE PLANNING OF FOOT SURGERY AND INTELLIGENT DESIGN OF PERSONALIZED PLANTING PROSTHESES. MINECO. MINISTERIO DE ECONOMIA Y COMPETITIVIDAD Participant
DPI2016-76630-C2-1-R IN SILICON-IN VITRO ANALYSIS TOOL OF THE APPEARANCE PROCESS AND GROWTH OF ATEROMA PLATE MINISTERIO DE ECONOMIA, INDUSTRIA Y COMPETITIVIDAD Others

Publications

2016

  • Chaure J., Serrano C., Fernandez-Parra R., Pena E., Lostale F., Gregorio M.A.D. et al. On Studying the Interaction Between Different Stent Models and Rabbit Tracheal Tissue: Numerical, Endoscopic and Histological Comparison. Annals of Biomedical Engineering. 2016;:1-14.
  • Cilla M., Perez M.M., Pena E., Martinez M.A.. Effect of Diet and Age on Arterial Stiffening Due to Atherosclerosis in ApoE−/− Mice. Annals of Biomedical Engineering. 2016;44(7):2202-2217.
  • Grasa J., Sierra M., Lauzeral N., Munoz M.J., Miana-Mena F.J., Calvo B.. Active behavior of abdominal wall muscles: Experimental results and numerical model formulation. Journal of the Mechanical Behavior of Biomedical Materials. 2016;61:444-454.
  • Ruiz-Alejos D., Pena J.A., Perez M.M., Pena E.. Experiments and Constitutive Model for Deep and Superficial Fascia. Digital Image Correlation and Finite Element Validation. Strain. 2016;52(5):436-445.
  • Calvo B., Pascual G., Pena E., Perez-Kholer B., Rodriguez M., Bellon J.M.. Biomechanical and morphological study of a new elastic mesh (Ciberlastic) to repair abdominal wall defects. Journal of the Mechanical Behavior of Biomedical Materials. 2016;59:366-378.
  • Cordero A., Hernandez-Gascon B., Pascual G., Bellon J.M., Calvo B., Pena E.. Biaxial Mechanical Evaluation of Absorbable and Nonabsorbable Synthetic Surgical Meshes Used for Hernia Repair: Physiological Loads Modify Anisotropy Response. Annals of Biomedical Engineering. 2016;:1-8.

News U13

29 May

Cardiovascular disease and Computation: an innovative lecture by Prof. Shirley Jansen

Tomorrow, on the 30th of May, our Tissue & Scaffold Characterization Unit 13 organises the Conference “Understanding cardiovascular disease by means of Computation Fluid Dynamics” by Prof. Shirley Jansen. The event will take place at 12:30 in the I3A Seminar Room, Block 5, 2nd floor of the R&D Building in Campus Rio Ebro of Universidad de Zaragoza. Prof. Jansen is passionate about the importance of working alongside engineers to understand the mechanics behind many vascular pathologies such as aortic aneurysm, dissection, and peripheral arterial disease, and why close collaboration via a shared language of haemodynamics can shed light on risk[...]

08 Mar

The revolutionary path of research in NANBIOSIS and advice on Woman’s Day 2024

Our interview series delve into the journeys of 7 female researchers, their challenges, and the call for gender equality in science, inspiring the next generation. March 8th 2024, NANBIOSIS (Spain) Kicking off on 11F “International Day of Women and Girls in Science” 2024, and spanning all the way until Woman’s Day 2024, our interview series has aimed to highlight the life, career and opinions of some of the brilliant minds within our network. Today is time to wrap it up, and for this reason we present you a summary of each of them and a chance to take a deeper[...]

22 Feb

Women in NANBIOSIS part 3: Professor Fany Peña, her insights in research, parenthood, and persistence

Prof. Peña gives us her insightful point of view in overcoming challenges, embracing passion, and cultivating collaborative success towards career estabilization. February 2024, Unizar/CIBER-BBN, Zaragoza (Spain) The echo of our footsteps returns from the high ceilings filled with electrical conduits and gas pipes. An alarm sounds in the distance, while the warmth of the Zen Garden located in the center of the R&D Building reminds us once again that peace and progress will never be at odds. We continue forward across the maroon floor, towards one of the access gates that separate each wing of the building. After crossing it,[...]

10 Nov

Applications of data-driven dynamics to oncology and neuromodulation

On the 17th of November, CIBER-BBN group TME lab – NANBIOSIS U13 Tissue & Scaffold Characterization Unit. organises the Conference “Applications of data-driven dynamics to oncology and neuromodulation” by Dr. Michael Ortiz. Michael Ortiz a Frank and Ora Lee Marble Professor Emeritus of Aronautics and Mechanical Engineering at California Institute of Technology. Prior to his arrival at Caltech in 1995, he was Professor of Engineering at Brown University. Since 2020 he also holds positions as Research Chair in the Institute of Applied Mathematics, University of Bonn and as Adjunct Professor and Timoshenko Distinguished Fellow in the departments of Mechanical Engineering[...]

21 Oct

Microchannel capillarity pumping design by Prof. Guillermo Artana

On the 28th of October, we will be receiving the international visit at the  Unversity of Zaragoza from Dr. Guillermo Artana from Laboratorio de Fluidodinámica-Facultad de Ingeniería-Universidad de Buenos Aires. The title of the talk will be “Microchannel capillarity pumping design“. The invited lecture is programed within the framework of the European project “Heart On chip based on induced pluripotent Stem cell Technology for personalized Medicine (CISTEM)” and counts with European funding: Horizon 2020 – Research and Innovation Framework Programme / H2020-MSCA-RISE-2017, grant agreement No.778354 in wich the University of Zaragoza participates through CIBER-BBN group TME lab – NANBIOSIS U13[...]

05 May

Induced pluripotent stem cells in disease modelling and experimental therapies: cardiovascular perspective

On the 20th of May, we will be receiving an international visit at the  Unversity of Zaragoza from Pr. Józef Dulak from Jagiellonian University, Kraków, Poland. The title of the talk will be “Induced pluripotent stem cells in disease modelling and experimental therapies: cardiovascular perspective“. The invited lecture is programed within the framework of the European CISTEM project, in wich the University of Zaragoza participates through CIBER-BBN group TME lab – NANBIOSIS U13 Tissue & Scaffold Characterization Unit. The event will take place at 12:00 in the I3A SEMINAR (2nd floor) of Campus Rio Ebro, of University of Zaragoza Induced pluripotent[...]

22 Mar

The results of POSITION II highlighted by CORDIS: A pan-European alliance for the next generation of smart catheters

In the picture: microencapsulated cardiospheres 10X Captured Brightfield with DM_RGB_Brightfield with DM The European project POSITION-II has been selected for publication in the ‘Results in Brief’ section of the Community Research and Development Information Service (CORDIS) website. CORDIS is the European Commission’s primary source of results from the projects funded by the EU’s framework programmes for research and innovation (FP1 to Horizon 2020). The resulting short article has now been published on the CORDIS website in six languages. The European project POSITION II “A pilot line for the next generation of smart catheters and implants” is an alliance of European[...]

07 Feb

Women Scientists in your neighborhood: Estefanía Peña

The International Day of Women and Girls in Science on February 11 honor women’s significant achievements in science and place a much-needed focus on girls entering Science, Technology, Engineering, and Mathematics (STEM) careers. We want to take this day to congratulate all the women scientists, especially to our scientists at NANBIOSIS ICTS, some of whom take an active role in the organization of events to celebrate this day, as Estefanía Peña in the initiative “Women Scientists in your neighborhood” form the University of Zaragoza. Estefanía Peña is the Cientific Coordinator of Unit 13 of Tissue & Scaffold Characterization from t[...]

U13-Tissue & Scaffold Characterization Unit
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U14. Cell Therapy

JUMISC

U14. Cell Therapy

  • Scientific Director: Dra. Esther López Nieto elopez@ccmijesususon.com
  • Entities: Jesus Uson Minimally Invasive Surgery Centre (JUMISC)
  • Address: Carretera N-521, km 41, 10071 Cáceres
  • Phone: + 34 927 181 032
  • Web: JUMISC

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Description

Laboratory with an area of 81,02 m2 for cell biology and molecular biology techniques. The laboratory is also equipped with two cell culture rooms for the isolation, expansion and characterization of different cell types.

Active projects

Title Fundin: Organism Call: Funding source Role
SAF2017-90810-REDI Strategic Promotion and coordinated management of Nanbiosis: Pronanbiosis II Agencia Estatal de Investigación (AEI) Acciones de dinamización «REDES DE EXCELENCIA» -ICTS 2017 Partner
PICCOLO-732111 Multimodal highly-sensitive PhotonICs endoscope for improve in vivo COLOn Cancer diagnosis and clinical decision support European Commission-H2020 H2020-ICT-2016-1 Partner
0624_2IQBIONEURO_6_E Promotion of an R&I network in biological chemistry for the diagnosis and treatment of neurological diseases European Union Interreg : European Territorial Co-operation POCTEP Interreg España-Portugal Partner

U14-Cell Therapy
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U16. Surface Characterisation and Bacterial Colonization Unit

Ciber bbn

U16. Surface Characterisation and Bacterial Colonization Unit

  • Scientific Director: Prof. M Luisa González Martín mlglez@unex.es
  • Scientific Coordinator: Prof. M Luisa González Martín mlglez@unex.es
  • Entities: Universidad de Extremadura
  • Address: Avda Elvas, S/N, 06006, Badajoz, Spain
  • Phone: +34 924 289 532
  • Web: WEB
UEX
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Description

The objective of the Unit 16 is to support researchers in the analysis of surface properties, as well as to test and characterise surfaces against bacterial colonisation, allowing a broad understanding of the chemical and physical properties of surfaces.

The combination of the information on the elements present and their co-ordination state, given by the XPS technique, and the molecular structure of the surface provided by the ToF-SIMs equipment, provides the chemical characterisation of the upper layers of the surfaces.

The physical characterisation of the surfaces deals with properties such as surface free energy, hydrophobicity, topography, electrical and mechanical properties of the surfaces and surface forces. For this purpose, the Unit 16 has experience in handling different instruments such as goniometer, optical profilometer, zeta potential analyser and AFM. Its capabilities allow it to work with extended and powdered solids, including those of biological origin such as cells and bacteria.

Along with physical and chemical characterisation, the Unit 16 can provide testing services for microorganism adhesion, viability and biofilm formation on surfaces.

Surface analysis laboratory fulfils the ISO9001:2008 (ES050823-1).  Nanbiosis- U16-logo-ISO9001

Active projects

TitleFundin: OrganismCall: Funding source Role
SAF2017-90810-REDIStrategic Promotion and coordinated management of Nanbiosis: Pronanbiosis IIAgencia Estatal de Investigación (AEI)Acciones de dinamización «REDES DE EXCELENCIA» -ICTS 2017Partner
PICCOLO-732111Multimodal highly-sensitive PhotonICs endoscope for improve in vivo COLOn Cancer diagnosis and clinical decision supportEuropean Commission-H2020H2020-ICT-2016-1Partner
0624_2IQBIONEURO_6_EPromotion of an R&I network in biological chemistry for the diagnosis and treatment of neurological diseasesEuropean Union Interreg : European Territorial Co-operationPOCTEP Interreg España-PortugalPartner

Other projects

RefTitleFunding OrganismUnit Role
MAT2015-63974-C4-3-RSUPERFICIAL CHARACTERIZATION AND MICROBIAL ADHESION OF BIODEGRADABLE AND BIOREABSORBIBLE MATERIALS MAGNESIUM BASE FOR BONE REPAIRMINISTERIO DE ECONOMÍA Y COMPETITIVIDADWorking package
MAT2015-63974-C4-4-RFORMATION OF MICROBIAL BIOFILMS ON BIODEGRADABLE AND BIOREABSORBABLE MG MATERIALS FOR BONE REPAIR AND BIOCOMPATIBILITY OF THESE IN EXPERIMENTATION ANIMALSMINISTERIO DE ECONOMÍA Y COMPETITIVIDADParticipant
MAT2014-52905-REDTRESEARCH NETWORK FOR THE DEVELOPMENT OF FUNCTIONALIZED TITANIUM IMPLANTSMINISTERIO DE ECONOMÍA Y COMPETITIVIDADOberver
PCIN-2016-146SIGNAL IMPLANT FOR ACCESSION AND BONE GROWTHMINISTERIO DE ECONOMÍA Y COMPETITIVIDADOberver

Publications

2016

  • Monje A., Gonzalez-Garcia R., Fernandez-Calderon M.C., Hierro-Oliva M., Gonzalez-Martin M.L., Del Amo F.S.-L. et al. Surface topographical changes of a failing acid-etched long-term in function retrieved dental implant. Journal of Oral Implantology. 2016;42(1):12-16.
  • Constantino J.A., Delgado-Rastrollo M., Pacha-Olivenza M.A., Gonzalez-Martin M.L., Quiles M., Perez-Giraldo C. et al. In vivo bactericidal efficacy of the Ti6Al4V surface after ultraviolet C treatment. Journal of Orthopaedics and Traumatology. 2016;:1-9.
  • Rodriguez-Sanchez J., Gallardo-Moreno A.M., Bruque J.M., Gonzalez-Martin M.L.. Adsorption of human fibrinogen and albumin onto hydrophobic and hydrophilic Ti6Al4V powder. Applied Surface Science. 2016;376:269-275.
  • Constantino J.A., Delgado-Rastrollo M., Pacha-Olivenza M.A., Perez-Giraldo C., Quiles M., Gonzalez-Martin M.L. et al. In vivo bactericidal efficacy of farnesol on Ti6Al4V implants. Revista Espanola de Cirugia Ortopedica y Traumatologia. 2016;:-.
  • Crespo L., Hierro-Oliva M., Barriuso S., Vadillo-Rodriguez V., Montealegre M.A., Saldana L. et al. On the interactions of human bone cells with Ti6Al4V thermally oxidized by means of laser shock processing. Biomedical Materials (Bristol). 2016;11(1):-.
  • Pena-Gonzalez C.E., Garcia-Broncano P., Ottaviani M.F., Cangiotti M., Fattori A., Hierro-Oliva M. et al. Dendronized Anionic Gold Nanoparticles: Synthesis, Characterization, and Antiviral Activity. Chemistry – A European Journal. 2016;22(9):2987-2999.
  • Cordoba A., Hierro-Oliva M., Pacha-Olivenza M.A., Fernandez-Calderon M.C., Perello J., Isern B. et al. Direct Covalent Grafting of Phytate to Titanium Surfaces through Ti-O-P Bonding Shows Bone Stimulating Surface Properties and Decreased Bacterial Adhesion. ACS Applied Materials and Interfaces. 2016;8(18):11326-11335.

News U16

21 Feb

The NABIHEAL Project Pioneers Wound Healing with New Biomimetic Matrices

Nearly 40 scientists across 7 countries are pioneering this breakthrough in wound healing using a nobel and affordable bio-inspired, anti-bacterial matrix. In addition to the vast consortium, the project also comprises 5 small and medium-sized enterprises (SMEs) and 9 academic institutions. These were convened last February at the University of Granada to share insights, progress, and strategies. According to an article published by UGR at the beginning of this month, about 40 researchers involved in the project have attended a meeting to share results and progress. The Horizon Europe project NABIHEAL, coordinated by the Biomedical Research Networking Center (CIBER) at[...]

08 Nov

Impactful research with NANBIOSIS participation in the Poster Tour of CIBER-BBN & CIBEREHD Annual Conference.

2023 CIBER-BBN Annual meeting has taken place at Santemar Hotel, in Santander during November 6-7. This year the format of our annual conferences has been changed towards a collective event scheme between the CIBER-BBN and CIBEREHD thematic areas. On Monday 6 the scientific sessions werecommon for EHD and BBN, with appealing contents for the mixed audience. On Tuesday 7 EHD and BBN sessions will specific for each area in separate rooms (with common coffee break). Posters of both areas were on display in the exhibit hall throughout the entirety of the Annual Meeting. Moreover, at the “Posters & beers” session (Monday[...]

08 Nov

NANBIOSIS sesion in the CIBER-BBN and CIBEREHD annual meeting. SAFE-N-MEDTECH Project: Outcomes and Future Prospects.

The annual conference of the scientific áreas of CIBER (the most important Centre for Biomedical Research in Spain) are hotly awaited every year for the CIBER community as a foro to be updated about emerging key technologies and discuss about research lines and results, find new opportunities to collaborate and join efforts towards common objectives. Moreover, this year, the Annual Conference of CIBER-BBN (Bioengineering, Biomaterials and Nanomedicine) has been organized as a collective event scheme together with the scientific area of CIBEREHD (Digestive and Liver Diseases). Both areas have already shared experiences of collaborative projects, demonstrating the complementarity of their fields.[...]

03 Jun

Representatives of the Ministry of Science and Innovation visited unit 16 of NANBIOSIS

On May 16 representatives of the General Subdirectorate of Large Scientific-Technical Facilities of the Ministry of Science and Innovation visited unit 16 of NANBIOSIS (created by Centro de Investigación Biomédica en Red -CIBER-, and the University of Extermadura). Mrs. Beatriz Albella Rodríguez and Mrs. María Jesús Marcos Crespo, got to know first-hand the facilities of unit 16 of the CTS NANBIOSIS of “Surface Characterization and Calorimetry“. The visit was guided by the Scientific Director of Unit 16 of NANBIOSIS, Maria Luisa González Martín, and by Mr. Javier de Francisco Morcillo, Director of the Secretariat for Scientific Infrastructure and Technological Development[...]

12 May

NABIHEAL project launches website

The website for NABIHEAL, an EU-funded Horizon Europe project developing biomaterials for complex wound healing, is now online. The Horizon Europe project NABIHEALi project is coordinated by the Center for Biomedical Research Network (CIBER) at the Institute of Materials Science of Barcelona (ICMAB-CSIC). This project will apply one the “Cutting Edge Biomedical Solutions” of NANBIOSIS for the preparation of different nanoestructures with antimicrobial properties, required for the development of the final multifunctional wound healing biomaterials. This case will gather the expertise of two NANBIOSIS unit: NANBIOSIS U6 will produce and characterize these nanoestructures with antimicrobial properties, which will be tested in NANBIOSIS U16. Find out mor[...]

24 Mar

NANBIOSIS U16 enlarges its capacities with a new FlexPS-ARPES-E kit

NANBIOSIS unit 16 Surface Characterization and Calorimetry Unit form CIBER-BBN and University of Extremadura has recently incorporated new equipment acquired through the execution of the project FICTS1420-14-09, cofinanced with FEDER funds, the Ministry of Economy and Competitiveness and Junta de Extremadura, Regional Ministry of Economy, Science and Digital Agency. A new FlexPS-ARPES-E kit, manufactured by SPECS, is now available for use by researchers This new resource uses the technique of photoelectron spectroscopy generated by X-rays to analyze the chemical composition of a surface. The electrons given off by the irradiated surface generate a fingerprint of the molecules that make up that surface, yielding information[...]

16 Jan

New European Project NABIHEAL in biomaterials for complex wound healing

The Horizon Europe project NABIHEAL, coordinated by the Center for Biomedical Research Network (CIBER) at the Institute of Materials Science of Barcelona (ICMAB-CSIC), was launched on 11-12 January 2023 in Barcelona with the first meeting of the international consortium, formed by 14 partners from 7 countries, including research centers, universities, and private companies.  This project will apply one the “Cutting Edge Biomedical Solutions” of NANBIOSIS for the preparation of different nanoestructures with antimicrobial properties, required for the development of the final multifunctional wound healing biomaterials. This case will gather the expertise of two NANBIOSIS unit: NANBIOSIS U6 will produce and[...]

10 Aug

New leaflets available of new equipment at NANBIOSIS Unit 16

We are delighted to announce the publication of our new brochures which reflects the new equiments and capabilities incorporated to NANBIOSIS U16 Surface Characterization and Calorimetry Unit. The equipment is available has been incorporated to the Unit thanks to European Regional Development Fund (FEDER) allocated by the Goberment of Spain for the development of ICTSs, specifically through the Project FICTS-1420-14-09. TOFSIMS_EN-1Download Profilometry_ENDownload Goniometer_ENDownload Further information: NANBIOSIS News[...]

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U17. Confocal Microscopy Service

Ciber bbn

U17. Confocal Microscopy Service

  • Scientific Director: Dr. Gemma Pascual gemma.pascual@uah.es
  • Scientific Coordinator: Dr. Selma Benito  selma.benito@uah.es
  • Technical Coordinator:  Mª Isabel Trabado unidad.cultivos@uah.es
  • Entities: Cell Culture Unit. Modulo IV, Planta Baja. Facultad de Medicina Universidad de Alcalá (UAH)
  • Address: Ctra. Madrid-Barcelona, km. 33,6, 28871, Alcalá de Henares, Madrid, Spain
  • Phone: +34 918 854 535
  • Web: WEB

UAH

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Description

Located in the Cell Culture Unit, Faculty of Medicine, University of Alcalá, has a room perfectly suited to host a Confocal Microscope service that provides 4 lasers and cell incubation cabin. This Unit is coordinated by Dr. Gemma Pascual, PI of the Translational Research and Tissue Engineering Group at the University of Alcalá.

Services

FOR THOSE SERVICES IDENTIFIED AS OUTSTANDING, AT LEAST 20% OF THEIR CAPACITY IS OPEN UNDER COMPETITIVE ACCESS. SEE ANNEX 1 OF ACCESS PROTOCOL FOR DETAILS ON % OF OPENNESS FOR EACH SERVICE

U17. Services & Rates

Active projects

Title Fundin: Organism Call: Funding source Role
SAF2017-90810-REDI Strategic Promotion and coordinated management of Nanbiosis: Pronanbiosis II Agencia Estatal de Investigación (AEI) Acciones de dinamización «REDES DE EXCELENCIA» -ICTS 2017 Partner
PICCOLO-732111 Multimodal highly-sensitive PhotonICs endoscope for improve in vivo COLOn Cancer diagnosis and clinical decision support European Commission-H2020 H2020-ICT-2016-1 Partner
0624_2IQBIONEURO_6_E Promotion of an R&I network in biological chemistry for the diagnosis and treatment of neurological diseases European Union Interreg : European Territorial Co-operation POCTEP Interreg España-Portugal Partner

Publications

2016

  • Pascual G., Sotomayor S., Adel F., Perez-Kohler B., Rodriguez M., Cifuentes A. et al. Remodeling of Noncrosslinked Acellular Dermal Matrices in a Rabbit Model of Ventral Hernia Repair. European Surgical Research. 2016;:32-48.
  • Calvo B., Pascual G., Pena E., Perez-Kholer B., Rodriguez M., Bellon J.M.. Biomechanical and morphological study of a new elastic mesh (Ciberlastic) to repair abdominal wall defects. Journal of the Mechanical Behavior of Biomedical Materials. 2016;59:366-378.
  • Cordero A., Hernandez-Gascon B., Pascual G., Bellon J.M., Calvo B., Pena E.. Biaxial Mechanical Evaluation of Absorbable and Nonabsorbable Synthetic Surgical Meshes Used for Hernia Repair: Physiological Loads Modify Anisotropy Response. Annals of Biomedical Engineering. 2016;:1-8.

News U17

03 Jun

How to accomplish researchers’ goals with Confocal Microscopy: the tools, the know-how and the expertise you need

NANBIOSIS Unit 17 (Confocal Microscopy) is a CIBER-BBN unit located in the Cell Culture Unit, CAI Medicine and Biology, Faculty of Medicine at the University of Alcala. This unit of the ICTS NANBIOSIS supports researchers interested on their different studies visualizing diverse samples as tissues, cells, bacterial biofilms, etc. This unit owns the tools, the know-how and the expertise to accomplish researchers’ goals either by transmission or reflection fluorescent. We are happy of sharing this video in which researchers of Unit 17 show all the steps required for the visualization of the PV-1 molecule, also known as PLVAP, on t[...]

18 Apr

Experimental & molecular medicine: a new article with NANBIOSIS U17

ICTS-NANBIOSIS. UNIT 17 CONFOCAL MICROSCOPY SERVICE. (CIBER-BNN. UNIVERSITY OF ALCALÁ) The UAH research groupTranslational research of chronic diseases associated with aging and kidney disease has recently published an article in which unit NANBIOSIS unit 17 and Leica SP5 confocal microscope has had a great contribution Located in the Support Center for Research in Medicine and Biology, Faculty of Medicine and Healthe Sciences, University of Alcalá (UAH). The Unit is equipped with a Leica TCS-SP5 confocal microscope. The confocal module is equipped with three spectral detection channels, AOBS (Acousto-optical beam splitter) and a resonant scanner system that allows analysis at hig[...]

17 Feb

The integrin beta1 modulator Tirofiban prevents adipogenesis and obesity by the overexpression of integrin-linked kinase: a pre-clinical approach in vitro and in vivo

Obesity is caused by the enlargement of the white adipose tissue (WAT) depots, characterized by the hypertrophic enlargement of malfunctioning adipocytes within WAT, which increases the storage of triglycerides (TG) in the lipid droplets (LD). Adipogenesis pathways as well as the expression and activity of some extracellular matrix receptors integrins are upregulated. Integrinβ1 (INTB1) is the main isoform involved in WAT remodeling during obesity and insulin resistance-related diseases. We recently described Integrin Linked Kinase (ILK), a scafold protein recruited by INTB1, as an important mediator of WAT remodeling and insulin resistance. As the few approved drugs to fight obesity hav[...]

08 Oct

“Ring Around the Rosy”

C2C12 myoblast cells differentiating into myotubes and adopting unusual shapes have been obtained and captured by resarchers of UAH and NANBIOSIS Unit 17 Confocal Microscopy Service (of CIBER-BBN and UAH) and and chosen photo of the month by the Spanish Society of Biochemistry and Molecular Biology (SEBBM) The picture illustrates the month of October on the calendar that the SEBBM publishes and distributes annually among all partners, and is part of the gallery of images that illustrate the activities of the SEBBM. Likewise, the photography will participate in the “Best Scientific Image of the Year” contest. The winning image is[...]

25 Apr

Uraemic toxins impair skeletal muscle regeneration by inhibiting myoblast proliferation, reducing myogenic differentiation, and promoting muscular fibrosis

Elena Alcalde‑Estévez, Patricia Sosa, Ana Asenjo‑Bueno, Patricia Plaza, Gemma Olmos, Manuel Naves‑Díaz, Diego Rodríguez‑Puyol, Susana López‑Ongil & María P. Ruiz‑Torres, are the authors of an article recently published in the Journal Scientific Reports, of Nature Research, ·mentioning the collaboration in the investigation of the ICTS “NANBIOSIS” U17 Confocal Microscopy Service of CIBER-BNN and the University of Alcalá. Uremic toxins (UT) increase in the serum in parallel with a decrease in the glomerular filtration rate and the development of sarcopenia in patients with chronic kidney disease (CKD). This study analyses the role of UTs in sarcopenia associated with CKD in different[...]

07 Apr

Toxicity evaluation on non-target organisms with the collaboration of NANBIOSIS U17 Confocal microscopy

Sara Jiménez-Jiménez, Georgiana Amariei, Karina Boltes, María Ángeles García and María Luisa Marina have recently published an article in the Journal of Chromatography A, ·mentioning the collaboration in the investigation of the ICTS “NANBIOSIS” U17 Confocal Microscopy Service of CIBER-BNN and the University of Alcalá. The echocytotoxicity of racemic panthenol and dexpanthenol at different concentrations and exposure times in Spirodela polyrhiza has been studied using NANBIOSIS U17 Confocal Microscopy Service “Panthenol (racemic mixture) and its isomer dexpanthenol have been classified as toxic for the aquatic environment by the European Regulation (EC 1272/2008). These studies are based on the natural emission[...]

11 Feb

NANBIOSIS Scientific Women in the International Day of Women and Girls in Science

Today February 11 is the International Day of Women and Girls in Science, a day to raise awareness of the gender gap in science and technology. According to the United Nations, while yet women and girls continue to be excluded from participating fully in science, science and gender equality are vital to achieve the internationally agreed development goals, including the 2030 Agenda for Sustainable Development. Thus, in recent years, the international community has made a great effort to inspire and promote the participation of women and girls in science. NANBIOSIS wants to acknowledge  the efforts made by scientific women who struggle every day to contribut[...]

13 Jul

Cardiac hypertrophy research with NANBIOSIS unit 17 Confocal Microscopy Service participation

A new article has been recently published about Cardiac hypertrophy research in the Scientific Reports Jorunal by NatureResarch, counting with the expertise of NANBIOSIS unit 17 Confocal Microscopy Service form CIBER-BBN and University of Alcalá de Henares. Cardiac hypertrophy is the abnormal enlargement, or thickening, of the heart muscle, resulting from increases in cardiomyocyte size and changes in other heart muscle components, such as extracellular matrix. This article relates more especifically with the link between long term exposure to xenoestrogen Bisphenol-A and adverse cardiovascular effects and the role of necroptosis in cardiac response to BPA had not yet been explored.[...]

U17-Confocal Microscopy Service
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U18. Nanotoxicology Unit

Ciber bbn

U18. Nanotoxicology Unit

    • Scientific Director: Prof. Ramón Mangues rmangues@santpau.cat
    • Scientific Coordinator: Dra.Isolda Casanova ICasanova@santpau.cat
    • Entities: Institut de Recerca. Hospital de la Santa Creu i Sant Pau 
    • Address: Hospital Santa Pau. c/Sant Antoni M. Claret, 167, 08025, Barcelona
    • Phone: +34 935 537 918
    • Web: WEB

  SAN-PAU

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Description

This Unit is located in the Hospital de la Santa Creu i Sant Pau, in Barcelona, and is coordinated by Dr. Ramón Mangues, PI of the Oncogenesis and Antitumor Drug Group. The main objective of the Nanotoxicology Unit is to assess the toxicity of new drugs, nanoparticles or nanotechnology-based biomaterials in in vitro and in vivo systems, with the goal of optimizing lead compounds and identifying those with the highest probability of success in the preclinical programme due to their greater safety and tolerability or reduced toxicity. The Unit has rooms equipped for cell culture, for cryopreservation of samples and cell lines, and for sample preparation and analysis and animal facilities for in vivo experimentation.

Equipment: The Unit has access to flow cytometers, sorters, confocal microscope and other equipment of the Platforms available at the Hospital Research Institute as well as housing facilities for small rodents (rat and mouse).

Active projects

Title Fundin: Organism Call: Funding source Role
ICTS-2017-10-CIBER-2 Acquisition and istallation of infrastrucuture to complemntUnis 3-Synthesis of Peptides, U18-Nanotoxicology y U20-In vivoExperiment Ministerio de Economía, Industria y Competitividad (MINECO) Programa Operativo FEDER de Crecimiento Inteligente 2014-2020 (POCInt) Coordinator
SAF2017-90810-REDI Strategic Promotion and coordinated management of Nanbiosis: Pronanbiosis II Agencia Estatal de Investigación (AEI) Acciones de dinamización «REDES DE EXCELENCIA»
-ICTS 2017
Coordinator

Other projects

Ref Title Funding Organism Unit Role
PI15/00378 Intelligent nanoconjugates for targeted therapy of metastatic colorectal cancer (CRC) Instituto de Salud Carlos III Working package
PIE15/00028 Targeted nanocongugates for the selective elimination of stem cells in disseminated cancer Instituto de Salud Carlos III Working package
PI15/00272 Design of intelligent nanoconjugates for the treatment of metastatic colorectal cancer. Instituto de Salud Carlos III Participant
CP15/00163 Maria Virtudes Céspedes Navarro Contracts Miguel Servet Type I Instituto de Salud Carlos III Working package
CD14/00055 Contract SARA BORRELL Instituto de Salud Carlos III Working package
Marato 416/C/2030TV32013-132031 Genotoxic nanoparticles targeting colorectal cancer stem cells Marato TV3 Participant

Publications

2016

  • Cespedes M.V., Guillen M.J., Lopez-Casas P.P., Sarno F., Gallardo A., Alamo P. et al. Lurbinectedin induces depletion of tumor-associated macrophages, an essential component of its in vivo synergism with gem;citabine, in pancreatic adenocarcinoma mouse models. DMM Disease Models and Mechanisms. 2016;9(12):1461-1471.
  • Rueda F., Cespedes M.V., Sanchez-Chardi A., Seras-Franzoso J., Pesarrodona M., Ferrer-Miralles N. et al. Structural and functional features of self-assembling protein nanoparticles produced in endotoxin-free Escherichia coli. Microbial Cell Factories. 2016;15(1):-.
  • Céspedes MV, Unzueta U, Álamo P, Gallardo A, Sala R, Casanova I et al. Cancer-specific uptake of a liganded protein nanocarrier targeting aggressive CXCR4+ colorectal cancer models.Nanomedicine : nanotechnology, biology, and medicine. 2016;12(7):-.
  • Cespedes M.V., Fernandez Y., Unzueta U., Mendoza R., Seras-Franzoso J., Sanchez-Chardi A. et al. Bacterial mimetics of endocrine secretory granules as immobilized in vivo depots for functional protein drugs. Scientific Reports. 2016;6:-.
  • Vazquez E., Mangues R., Villaverde A.. Functional recruitment for drug delivery through protein-based nanotechnologies. Nanomedicine. 2016;11(11):1333-1336.
  • Serna N., Cespedes M.V., Saccardo P., Xu Z., Unzueta U., Alamo P. et al. Rational engineering of single-chain polypeptides into protein-only, BBB-targeted nanoparticles. Nanomedicine: Nanotechnology, Biology, and Medicine. 2016;12(5):1241-1251.
  • Cano-Garrido O, Céspedes MV, Unzueta U, Saccardo P, Roldán M, Sánchez-Chardi A et al. CXCR4(+)-targeted protein nanoparticles produced in the food-grade bacterium Lactococcus lactis.Nanomedicine (London, England). 2016;11(18):-.
  • Rueda F., Gasser B., Sanchez-Chardi A., Roldan M., Villegas S., Puxbaum V. et al. Functional inclusion bodies produced in the yeast Pichia pastoris. Microbial Cell Factories. 2016;15(1):-.
  • Pesarrodona M., Fernandez Y., Foradada L., Sanchez-Chardi A., Conchillo-Sole O., Unzueta U. et al. Conformational and functional variants of CD44-targeted protein nanoparticles bio-produced in bacteria. Biofabrication. 2016;8(2):-.

News U18

04 Apr

Protein-only Materials offer a new hope in colorectal cancer treatment

Breakthrough colorectal cancer treatment unveiled by NANBIOSIS Units promises enhanced precision & efficacy in targeted cancer therapies. March 2024, UAB/Institut de Recerca Sant Pau/CIBER-BBN (Barcelona) As we leave World Colorectal Cancer Day 2024 behind, marked on March 31st, there have been significant highlights in cancer treatment, a field in which targeted therapies are playing a crucial role. In this context, researchers from the Nanobiotechnology team, at the Institut de Biotecnologia i de Biomedicina from Universitat Autònoma de Barcelona, led by Prof. Antonio Villaverde, in collaboration with the Oncogenesis and Antitumor Drugs team led by Prof. Ramón Mangues at Institut d[...]

05 Mar

New immunization research for SARS-CoV-2 with the collaboration of NANBIOSIS

This novel immunization platform, recently published in ACS, triggers potent antivirus response, promising efficient and cost-effective vaccination. March 2024, UAB/Vall d’Hebron Research Institute/CIBER-BBN (Barcelona) The battle against infectious diseases demands innovative solutions. The world is especially aware of this fact after facing threats such as the SARS-CoV-2 pandemic. In a very recent publication in ACS Materials Letters, researchers from the Universitat Autònoma de Barcelona (UAB) and Hospital de Sant Pau, both within the CIBER-BBN, have achieved a significant milestone in vaccine development. Their study, conducted in partnership with international teams as well as NANBIOSIS, has introduced a novel immunization approac[...]

06 Feb

‘Magic Bullets’ Against Cancer: Unveiling the Potential of DNA Nanoparticles

DNA nanoparticles to selectively target tumor tissues through precise control of the synergies between transported drugs. February 2024, IQAC-CSIC/CIBER-BBN, Barcelona. The team led by Drs. Carme Fàbrega and Ramón Eritja, in close collaboration with 3 units of the NANBIOSIS ICTS, has developed a new strategy to improve the efficacy and reduce the toxicity of anticancer drugs. They have chemically linked several cytotoxic drugs, currently used in the treatment of various types of tumors, to DNA nanostructures. These structures selectively target cancerous tissues through folate receptors. This tactic allows precise control of drug concentration and exploits their combined effect. The results[...]

20 Dec

Good News! Protein Nanoparticles with a New Ligand Select and Destroy Tumor-associated Fibroblasts”

With the participation of two units of NANBIOSIS ICTS and the expertise of the scientists managing these units The study, fruit of the collaboration between the Nanotechnology group of the Institute of Biotechnology and Biomedicine (IBB-UAB), led by Prof. Antonio Villaverde, and the Oncogenesis and Antitumor Drugs group of the Sant Pau Research Institute, led by Dr. Ramon Mangues, both members of CIBER-BBN, has made significant progress by identifying the natural ligand PDGFD as an effective tool to target protein nanoparticles to tumor-associated fibroblasts that overexpress the PDGFR-β receptor. Given the relevance of the discovery, this technology has been intellectually[...]

08 Nov

Impactful research with NANBIOSIS participation in the Poster Tour of CIBER-BBN & CIBEREHD Annual Conference.

2023 CIBER-BBN Annual meeting has taken place at Santemar Hotel, in Santander during November 6-7. This year the format of our annual conferences has been changed towards a collective event scheme between the CIBER-BBN and CIBEREHD thematic areas. On Monday 6 the scientific sessions werecommon for EHD and BBN, with appealing contents for the mixed audience. On Tuesday 7 EHD and BBN sessions will specific for each area in separate rooms (with common coffee break). Posters of both areas were on display in the exhibit hall throughout the entirety of the Annual Meeting. Moreover, at the “Posters & beers” session (Monday[...]

28 Sep

Nanoligent raised €2.8 M and completed Seed round financing with support of i&i Biotech Fund

September 27th 2022 – Nanoligent SL, a Spanish biotech company specialized in the development of cancer treatments based on unique protein conjugates, today announces the completion of a Seed financing round of total € 2.8 M. The final closing of the Seed round consists of € 1 M investment by i&i Biotech Fund I (i&i Bio), an early-stage Life Science fund with teams in Luxemburg and Prague which is backed by the European Investment Fund. i&i Bio joined previous Nanoligent investors, Italian Angels for Growth, the largest network of business angels in Italy, and AVANTECA Partners, a Swiss privately held[...]

02 May

Wide representation of NANBIOSIS research in NALS 2022 and best Oral Presentation to Eloi Parladé

During the last 27-29 April, the 3rd International Conference on Nanomaterials Applied to Life Sciences 2022 (NALS 2022) has taken place in the Excellence Campus of Universidad de Cantabria in Santander (Spain), organized by the University of Cantabria and Institute Valdecilla-IDIVAL. NALS 2022 has been a multidisciplinary conference series sharing new results and ideas in the fields of biosensors, lab on a chip, drug delivery nanopharmacy. nanobiotechnology, intelligent nanomaterials, magnetic materials, nanotoxicity, antimicrobials, novel applications of 3d bioprinting and nanoimaging. NANBIOSIS has been represented at this edition by members of several of its units, among them we must highlight the set of four ora[...]

03 Feb

Nanoligent, whoes founders are leaders of NANBIOSIS units, raises €1M in Series Seed financing

Barcelona, Spain – Milan, Italy, February 3rd, 2022 – Nanoligent SL, a biotech company specialized in the development of nanotechnology-based cancer treatments, today announces the completion of the first closing of a Seed financing round of €1M. The round has been led by members of Italian Angels for Growth, the largest network of business angels in Italy, through the investment vehicle Nanolinvest, and AVANTECA Partners, a Swiss privately held asset management firm, both specialized in supporting innovative early-stage life-science companies primarily in Europe. An equity campaign, is still ongoing on Doorway, an online investment platform, thus promising to provide additional funding[...]

U18-Nanotoxicology Unit
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U19. Animal Modelling Unit

JUMISC

U19-CLINICAL TESTS LAB
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U30. Proteomics

CIBER-BBN

U30 Proteomics
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