U6. Biomaterial Processing and Nanostructuring Unit
- Scientific Coordinator: Dr. Nathaly Segovia firstname.lastname@example.org
- Entities: Instituto de Ciencia de Materiales de Barcelona ICMAB-CSIC
- Address: Campus de UAB, 08193, Bellaterra, Barcelona, Spain
- Phone: +34 935 801 853
- Fax: +34 935 805 729
- Web: ICMAB
Located at the Instituto de Ciencia de Materiales de Barcelona (ICMAB-CSIC), in Barcelona, and under the coordination of Professor Jaume Veciana and Prof. Nora Ventosa, current directors of NANOMOL Group, which is a research group with wide expertise and recognized excellence in the synthesis, processing and study of molecular and polymeric materials with chemical, electronic, magnetic and biomedical properties. It gathers several laboratories, perfectly equipped, to perform the mission of this facility: the development, characterization, and large-scale production of molecular biomaterials of therapeutic or biomedical interest, with controlled micro-, nano- and supramolecular structure.
One example of Key-Enabling-Technology (KET) available in this unit is a simple one-step methodology, DELOS-SUSP, based on the use of compressed fluids (CF), such as CO2, to prepare particulate materials with precise and reproducible structural characteristics at micro-, nano- and supramolecular levels (size, shape, internal structural gradients, supramolecular organization and crystalline purity). This example shows one of the singularities of this unit is that counts with CF–based plants at different scales, from mL to L, which allow process development by QbD and process scale-up.
- U6-S01. Use of High-pressure laboratory-scale plant with 50, 100 and 300 m reactors for the processing of biomaterials. Processing of cytotoxic compounds when required. (Remote) OUTSTANDING
- U6-S02. High-pressure phase analysis – solubility, emulsification (Remote) OUTSTANDING
- U6-S03. Thermal analysis of solid materials(Remote) OUTSTANDING
- U6-S04. Analysis of particle size, concentration and Z-potential of nanoparticles (On-site&Remote) OUTSTANDING
- U6-S05. Analysis of particle morphology (Remote) OUTSTANDING
- U6-S06. Fluorescence spectroscopic analysis (On-site&Remote)
- U6-S07. UV-Vis spectroscopic analysis (On-site&Remote)
- U6-S08. Visual observation (On-site&Remote)
- U6-S09. Centrifugation (On-site)
- U6-S10. Treatment of sample by ultrasound probe (On-site)
- U6-S11. Specific density of powders (On-site&Remote) OUTSTANDING
- U6-S12. Packed (tapped) density(On-site) OUTSTANDING
- U6-S13. Detection of labeled nanoparticles and exosomes by fluorescence mode (On-site&Remote) OUTSTANDING
- U6-S14. Quantitative studies of biomolecular interactions by calorimetric measurements (On-site) OUTSTANDING
FOR THOSE SERVICES IDENTIFIED AS OUTSTANDING, AT LEAST 20% OF THEIR CAPACITY IS OPEN UNDER COMPETITIVE ACCESS. SEE ANNEX 1 OF ACCESS PROTOCOL FOR DETAILS ON % OF OPENNESS FOR EACH SERVICE
- U6-E01. High-pressure laboratory-scale plant with 50, 100 and 300 ml reactors for the processing of biomaterials.
- U6-E02. High-pressure phase analyzer for studying the thermodynamic behaviour of materials.
- U6-E03. Malvern Zetasizer Nano ZS particle size analyzer.
- U6-E04. Nanosight LM -20 for Nanoparticle Tracking Analysis.
- U6-E05. Nanosight NS-300 for Nanoparticle Tracking Analysis by fluorescence mode.
- U6-E06. Perkin-Elmer DSC 8500 differential scanning calorimeter.
- U6-E07. Olympus BX51 optical microscope with heating plate and fluorescence accessories.
- U6-E08. Perkin-Elmer LS 45 fluorescence spectrometer.
- U6-E09. Varian Cary 5 UV -Vis spectrometer.
- U6-E10. Quantachrome Ultrapyc 1200e helium pycnometer.
- U6-E11. Ultrasound probe and Autotap instrument for packed density measurements of powders.
- U6-E12. Malvern Morphologi G3 for advanced particle morphologi characterization.
- U6-E13. Microcalorimeter for measurements of biomolecular binding properties under Isothermal Titration Calorimetry (ITC)
- U6-E14. Four Glove Dispensing isolator for expermiments with highly active and cytotoxic compounds
Marta Mas-Torrent, Jaume Veciana, and Nuria Crivillers, scientists of the research group NANOMOL, coordinating NANBIOSIS U6. Biomaterial Processing and Nanostructuring Unit, are co-authors of the article “Carbon-gold bonds for robusts molecule-electrode junctions” by Journal of the American Chemical Society -JACS-. The researchers have studied the behaviour of an organic radical as a molecular wire formed by a covalent carbon-gold bond between the molecule and two electrodes. The molecule-metal junction is more stable and gemotrically better defined than its predecessors, in which other functional groups were used. This improvement opens up new horizons in the fabrication of novel electronic devices with applications[...]
Mesenchymal stem cells or exosomes with fibrin glue mesh fixation modulates the inflammatory reaction in a murine model of incisional hernia
Javier García Casado, Scientific Director of NANBIOSIS U14, Cell Therapy Unit, and Francisco Miguel Sánchez Margallo, Scientific Director of CCMIJU, are co-author of the publication “Fibrin glue mesh fixation combined with mesenchymal stem cells or exosomes modulates the inflammatory reaction in a murine model of incisional hernia” by Acta Biomaterialia. In vitro experiments were performed by the ICTS Nanbiosis (Unit 14. Cell therapy at CCMIJU). Exosomes characterization was performed by the ICTS Nanbiosis (Unit 6: Biomaterial processing and Nanostructuring Unit). In vivo experiments were performed by the ICTS Nanbiosis (Unit 22. Animal housing at CCMIJU). The study has demonstrated a[...]
The Fabry International Network (FIN) association established the month of April as the “month of Fabry” to raise awareness and educate about this disease, a rare, progressive and with multi-organ involvement pathology. Fabry Disease is one of several dozen Lysosomal Storage Disorders that interfere with the body’s ability to break down specific fatty substances. It is a rare disease and because the rate of occurrence is less than 1 in 200,000, it is considered as one of the many “Orphan” diseases. It is more common in women, but it occurs with greater severity in men. Fabry disease is a metabolic[...]
Nora Ventosa, Scientific Director of NANBIOSIS U6, presented the Smart4Fabry project to the compressed fluids community
Last 25th April, Nora Ventosa, Scientific Director of NANBIOSIS U6. Biomaterial Processing and Nanostructuring Unit, presented Smart4Fabry project to the compressed fluids community at the 12th International Symposium on Supercritical Fluids in Antibes, France. This event is held every three years, gathering investigators from all domains with the aim to promote knowledge and applications of Supercritical Fluids. According to the ISASF, International Society for Advancement of Supercritical Fluids, “a fluid is called “supercritical” when both its pressure and temperature are over its critical pressure and temperature. It is monophasic and exhibits specific properties, different from those of liquids and gases. Supercritical fluids have a hig[...]
Robust Organic Radical Molecular Junctions Using Acetylene Terminated Groups for C–Au Bond Formation
Jaume Veciana, Scientific Director of NANBIOSIS is co-author of the publication “Robust Organic Radical Molecular Junctions Using Acetylene Terminated Groups for C–Au Bond Formation” by “Journal of the American Chemical Society”. For further information: DOI: 10.1021/jacs.7b10019 J. Am. Chem. Soc., 2018, 140 (5), pp 1691–1696[...]
Scientists from two NANBIOSIS units participate in two of the three projects selected in the Call CIBER-BBN / CIBERONC. On April 13, the 1st CIBERONC – CIBER-BBN Collaborative Projects Forum took place at the National School of Health (Carlos III Health Institute). The purpose of the event was to carry out the resolution of the call for collaborative seed projects between the two areas. During the forum, 12 proposals for collaborative projects were presented, encompassed in four thematic sessions: new nano-devices, new strategies for 3D culture, phototherapy and drug release. All the proposals included the application of some of t[...]
“Smart-4-Fabry”: European project focused on the Fabry rare disease, participated by 4 units of NANBIOSIS
Smart-4-Fabry is a project coordinated by CIBER-BBN, funded by the European Commission within the Horizon 2020 Research and Innovation program with € 5.8 M for 4 years, which aims to develop a new nanomedicine for the treatment of the Fabry rare disease. Fabry disease is a rare disease belonging to the group of lysosomal storage disorders, with a global incidence of 1:5,000 – 1:10,000, representing a priority health problem at European level. The European project “Smart-4-Fabry”, is coordinated by CIBER-BBN, specifically by NANOMOL group at ICMAB-CSIC (Dr. Nora Ventosa) and the Biomaterial Processing and Nanostructuring Unit (U6) of ICTS “NANBIOSIS”, and it[...]
NANBIOSIS ICTS invites groups and companies to discuss Smart Biomaterials and devices for Drug Delivery
On February 22nd, the National School of Health of the Carlos III Health Institute hosted the forum on Smart Biomaterials and biomedical devices for applications in drug delivery and regenerative medicine, organized by the ICTS Nanbiosis, an infrastructure shared by the CIBER-BBN and the Center of Minimally Invasive Surgery Jesus Usón (CCMIJU). This is the first groups/companies meeting organized by Nanbiosis, in which about 70 B2B meetings were held. The meeting brought together about 40 participants from 14 research groups (from the CIBER-BBN and the CCMIJU) and 10 companies, which discussed the latest advances in the research lines developed by the groups[...]