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News U13

Induced pluripotent stem cells in disease modelling and experimental therapies: cardiovascular perspective

On the 20th of May, we will be receiving an international visit at the  Unversity of Zaragoza from Pr. Józef Dulak from Jagiellonian University, Kraków, Poland. The title of the talk will be “Induced pluripotent stem cells in disease modelling and experimental therapies: cardiovascular perspective“.

The invited lecture is programed within the framework of the European CISTEM project, in wich the University of Zaragoza participates through CIBER-BBN group TME lab NANBIOSIS U13 Tissue & Scaffold Characterization Unit.

The event will take place at 12:00 in the I3A SEMINAR (2nd floor) of Campus Rio Ebro, of University of Zaragoza

Induced pluripotent stem cells (iPSC) are generated by genetic reprogramming of somatic cells and thanks to the ability to differentiate into almost all cells types of the organism they offer the enormous possibilities for investigating disease mechanisms, drug sensitivity and safety and for experimental regenerative approaches.  iPSC thus became the indispensable tools of current medial biotechnology and received additional input thanks to the development of the CRISPR/Cas9 gene editing.

In this lecture PR. Józef Dulak will review his research in which iPSC and CRISPR/Cas9 gene editing is applyed for investigating the iPSC-differentiation to cardiomyocytes, endothelial cells and other cell types linked with the disease affecting vascular system, heart and the skeletal muscles. The special attention will be on discussing the potential of iPSC for diabetes and Duchenne muscular dystrophy disease modelling.

Application of iPSC-derived cardiomyocytes offer the chance for effective cell therapy of heart failure and this will be addressed in regard to recently published studies.

  1. Sci Rep. 2015 Feb 26;5:8597. doi: 10.1038/srep08597.
  2. Stepniewski J, et al., Dulak J. Heme oxygenase-1 affects generation and spontaneous cardiac differentiation of induced pluripotent stem cells. IUBMB Life. 2018 Feb;70(2):129-142. doi: 10.1002/iub.1711. 2018 Jan 9.
  3. Kachamakova-Trojanowska N, Stepniewski J, Dulak J.  Human iPSCs-derived endothelial cells with mutation in HNF1A as a model of maturity-onset diabetes of the young. Cells. 2019 Nov 14;8(11). pii: E1440. doi: 10.3390/cells8111440.
  4. Stępniewski J, et al. Dulak J.  Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes, in Contrast to Adipose Tissue-Derived Stromal Cells, Efficiently Improve Heart Function in Murine Model of Myocardial Infarction. Biomedicines. 2020 Dec 7;8(12):578. doi: 10.3390/biomedicines8120578.
  5. Jeż M, et al. Dulak J.  Role of Heme-Oxygenase-1 in Biology of Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells. Cells. 2021 Mar 1;10(3):522. doi: 10.3390/cells10030522.
  6. Andrysiak K, Stępniewski J, Dulak J. Human-induced pluripotent stem cell-derived cardiomyocytes, 3D cardiac structures, and heart-on-a-chip as tools for drug research. Pflugers Arch. 2021 Jul;473(7):1061-1085. doi: 10.1007/s00424-021-02536-z. Epub 2021 Feb 24.
  7. Martyniak A, et al, Dulak J. Generation of microRNA-378a-deficient hiPSC as a novel tool to study its role in human cardiomyocytes. J Mol Cell Cardiol. 2021 Jul 28;160:128-141. doi: 10.1016/j.yjmcc.2021.07.007.  
  8. Kachamkova-Trojanowska N, Skoczek D, Dulak J,  Maturity Onset Diabetes of the Young – new approaches for disease modelling. Int J Mol Sci. 2021 Jul 14;22(14):7553. doi: 10.3390/ijms22147553.
  9. Andrysiak K, et al., Dulak J. Generation of DMBi002-A human induced pluripotent stem cell line from patient with Spinal muscular atrophy type 3. Stem Cell Res. 2021 Oct 13;57:102563. doi: 10.1016/j.scr.2021.102563. 
  10. Jelinkova S, Martyniak A, Dulak J, Stępniewski J.   Derivation of human pluripotent stem cell line via CRISPR/Cas9 mediated deletion of exon 3 LAMA2 gene (DMBi001-A-1) Stem Cell Res. 2021 Sep 2;56:102529. doi: 10.1016/j.scr.2021.102529
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The results of POSITION II highlighted by CORDIS: A pan-European alliance for the next generation of smart catheters

In the picture: microencapsulated cardiospheres 10X Captured Brightfield with DM_RGB_Brightfield with DM

The European project POSITION-II has been selected for publication in the ‘Results in Brief’ section of the Community Research and Development Information Service (CORDIS) website. CORDIS is the European Commission’s primary source of results from the projects funded by the EU’s framework programmes for research and innovation (FP1 to Horizon 2020).

The resulting short article has now been published on the CORDIS website in six languages.

The European project POSITION II “A pilot line for the next generation of smart catheters and implants” is an alliance of European leaders, united to improve technology and offer cheaper, easier to use, more efficient and technologically advanced catheters by incorporating sensors and real-time positioning and monitoring systems. This new generation of catheters will improve the treatment of multiple pathologies, through new therapeutic tools such as cell therapy and tissue engineering implemented in the project by the U10 Drug Formulation of the ICTS Nanbiosis, which is integrated in the NanoBioCel group of CIBER-BBN and UPV/EHU.

The following actions have been carried out in NANBIOSIS U10 Drug Formulation during the execution of the project:

– Isolate, expand and characterize cardiosphere-derived cells (CDCs). CDCs were  isolated from porcine cardiac tissue, and their  release profile of immunomodulatory factors was determined.

– To optimize the encapsulation conditions of CDCs in alginate microcapsules.

– Evaluate whether the physical and chemical properties of the encapsulated CDCs were suitable for the catheter developed in the project.

– Determine that the secretion profile of trophic factors did not change in CDCs after encapsulation.

– Provide the TME Lab group and NANBIOSIS U13 of CIBER-BBN and the University of Zaragoza with the microcapsules and encapsulated CDCs required for their mechanical characterization and to evaluate the behavior of the capsules in the catheter and in the animals at the NANBIOSIS units of Center for Minimally Invasive Surgery in Extremadura (CCMIJU). Other collaborations during the execution of the project were established with the Fraunhofer EMFT group in Germany and with the Spanish company IberHospitex, manufacturer of the catheters.

Other related news:

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Women Scientists in your neighborhood: Estefanía Peña

The International Day of Women and Girls in Science on February 11 honor women’s significant achievements in science and place a much-needed focus on girls entering Science, Technology, Engineering, and Mathematics (STEM) careers. We want to take this day to congratulate all the women scientists, especially to our scientists at NANBIOSIS ICTS, some of whom take an active role in the organization of events to celebrate this day, as Estefanía Peña in the initiative “Women Scientists in your neighborhood” form the University of Zaragoza.

Estefanía Peña is the Cientific Coordinator of Unit 13 of Tissue & Scaffold Characterization from the ICTS NANBIOSIS since the creation of the Unit in 2007 by the Network Biomedical Research Center in Bioengineering, Biomaterials and Nanomedicine, (CIBER-BBN) and the University of Zaragoza-I3A. Estefanía participates this year in the Campaign “I’m a Scientist, I live in your neighborhood” organised by Scientific Culture Unit of the University of Zaragoza to break stereotypes that present the women scientists as heroines, geeks or with little social life, while the scientists who live in our neighborhoods show the reality of a vibrant and exciting career choice, to vindicate the role of women in science, break the gender gap and offer close references to girls and adolescents.

“My name is Estefanía Peña and I am Professor of Mechanics of Continuous Media and Theory of Structures at the School of Engineering and Architecture. In addition to teaching, I am dedicated to research in the field of Biomedical Engineering at the Engineering Research Institute of Aragon (I3A).

I am delighted to share with you the story of why I ended up being a scientist and dedicated myself to research in Engineering applied to Life Sciences. I was born in Zaragoza and have lived in Zaragoza practically all my life, except for a few short periods in France and England. From a very young age I liked science, but I have always had a split heart between physics and mathematics and literature and history. Since I was little, I also liked teaching, and my classmates know that in exchange for a snack I gave classes to whoever asked me. In the end I opted for mathematics and physics, because I was attracted to knowing when and why things happened, and since then I have dedicated much of my time to continue learning about the world around us and reading books in my spare time. literature and history, the mountains and gardening. I have always had the support of my family and friends who have understood and supported a woman dedicating herself to a field that until a few years ago was traditionally masculine and now is no longer. Just to say that among my colleagues we are equal parts men and women. I have a fantastic family and being a mother has made me value even more the things I do and what I dedicate my time to. That is why I know that dedicating myself to research and teaching is something fantastic and that it fills me with gratitude to know how lucky I am.

I started my Engineering career in the specialty of structures and then the doctorate in Biomechanics, the branch of Engineering that applies the principles of Mechanics to Life Sciences such as Biology, Veterinary Medicine and Medicine. I was especially attracted to this field because I find that applying Engineering to something as warm and rewarding as trying to improve people’s lives every day is an exciting profession, developing diagnostic, treatment and/or surgical techniques, medical instruments and devices and treating to contribute a grain of sand to make this world better. In my work I live surrounded by great people, I love meeting new people, helping to train new scientists and enriching myself with knowledge.

I am delighted to participate in this initiative with my colleagues, all of them fantastic scientists who in their day to day show that science is open to women and that it is a fascinating way to make this world a little better.”

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NANBIOSIS Scientific Women in the International Day of Women and Girls in Science

Today February 11 is the International Day of Women and Girls in Science, a day to raise awareness of the gender gap in science and technology.

According to the United Nations, while yet women and girls continue to be excluded from participating fully in science, science and gender equality are vital to achieve the internationally agreed development goals, including the 2030 Agenda for Sustainable Development. Thus, in recent years, the international community has made a great effort to inspire and promote the participation of women and girls in science.

NANBIOSIS wants to acknowledge  the efforts made by scientific women who struggle every day to contribute their bit to Science and highlight their essential role in nowadays research. Especially we want to recognize the work of scientists women involved in NANBIOSIS, whatever is the nature of their contribution: technical, scientific development, management, coordination, direction, etc; just to mention some examples:
Neus Ferrer and Mercedes Márquez in the Scientific Direction and Coordination of Unit 1 Protein Production Platform (PPP)
Pilar Marco and Nuria Pascual in the Management and Scientific Coordination of U2 Custom Antibody Service (CAbS) 
Miriam Royo in the Scientific Direction of U3 Synthesis of Peptides Unit
Nora Ventosa and Nathaly Segovia in the Scientific Direction and Technical Coordination of U6 Biomaterial Processing and Nanostructuring Unit
Isabel Oliveira and Teresa Galán in the Coordination of U7 Nanotecnology Unit
Rosa Villa and Gemma Gabriel in the Management and Scientific Coordination of U8 Micro – Nano Technology Unit
Gema Martínez in the Scientific Coordination of U9 Synthesis of Nanoparticles Unit
Fany Peña in the Scientific Coordination of U13 Tissue & Scaffold Characterization Unit
Mª Luisa González Martín and Margarita Hierro in the of Direction and Scientific Coordination of U16 Tissue & Scaffold Characterization Unit
Gemma Pascual and Isabel Trabado in the Coordination of the U17 Confocal Microscopy Service
Isolda Casanova in the Scientific Coordination of U18 Nanotoxicology Unit
Beatriz Moreno in the Scientific Direction of Unit 19 Clinical tests lab
Ibane Abásolo in the Scientific Coordination of Unit 20 In Vivo Experimental Platformt
Verónica Crisóstomo in the Scientific Direction of Unit 24 Medical Imaging 
Ana Paula Candiota in the Scientific Coordination of Unit 25 Biomedical Applications I 
Maria Luisa García in the Scientific Direction of U28 NanoImaging Unit from Bionand, recently incorporated to NANBIOSIS, Anna Aviñó in the Scientific Coordination of U29 Oligonucleotide Synthesis Platform (OSP) – and

Nerea Argarate in the coordination of NANBIOSIS

Thanks to all of you and your teams!

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The University of Zaragoza, in the elite of the 500 best universities in the world

The Academic Ranking of World Universities (ARWU), known as
Shanghai Ranking, which was made public on August 15, once again places the University of Zaragoza among the elite of the 500 best universities in the world.

This indicator organizes up to 20,000 university centers worldwide. Among the keys that have been able to positively influence the results of the research, according to the Vice Chancellor for Prospect, Sustainability and Infrastructure of the University of Zaragoza, Francisco Serón, are the increase in public campus funding for four years as well as the quality of their Scientists.

The University of Zaragoza houses three of NANBIOSIS Units:

U9 Synthesis of Nanoparticles Unit, led by Jesús Santamaría and Gema Martínez

U13 Tissue & Scaffold Characterization Unit, led by Miguel Ángel Martínez Barca and Fany Peña

U27 High Performance Computing , led by Pablo Laguna

Since 2003, every August, the Academic Ranking of World Universities (ARWU), known as “Shanghai Ranking,” is published, one of the international reference studies to compare higher education institutions. The ranking selects the 1,000 best educational institutions from a global point of view, among the 20,000 higher education centers that exist.

It is possibly the most famous and most recognized university analysis that values the quality of institutions in the generation of knowledge. The research community respects the results of these rankings because they are based on objective data and their classification is reproducible.

Source:
https://www.aragondigital.es/2019/08/15/la-uz-en-la-elite-de-las-500-mejores-universidades-del-mundo-segun-el-ranking-de-shanghai/

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Manuel Doblaré, researcher of NANBIOSIS U13, new Chairman of IMDEA Materials Foundation

Manuel Doblaré researcher of the Group Applied Mechanics and Bioengineering AMB and NANBIOSIS U13 Tissue & Scaffold Characterization Unit of CIBER-BBN and I3A presides, from this month, the Board of Trustees of the Imdea Materiales Foundation.

The IMDEA Materials Institute, one of the seven Madrid Institutes for Advanced Studies (IMDEA), is a public research centre founded in 2007 by Madrid’s regional government. The goal of the Institute is to do research at the forefront of Material Science and Engineering, attracting talent from all around the globe, and collaborating with companies in an effort to transfer fundamental and applied knowledge into valuable technology

In an interview by I3A-UZ Manuel Doblaré highlights from IMDEA its great evolution and major strategic lines, with projects lasting three or four years and the balance he has achieved between very powerful basic research and strong collaboration with the industry.

Manuel Doblaré was the founder of the I3A and the forst scientific director of the CIBER-BBN. Today, in addition to chairing the IMDEA Materials Foundation, he is a Fellow of the European Alliance for Engineering and Biomedicine (EAMBES) and the World Biomechanics Council, as well as the director of the Gadea Ciencia Foundation, whose objective is to promote the improvement and advancement of science, technology and innovation in Spain.

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Tumor Immunology and Cancer Immunotherapy Course

The IV course on Tumor Immunology and Cancer Immunotherapy will start on 6th Feb, 2020.

On April 2 at 7:00 pm Iñaki Ochoa will teach about “Basic research in cancer immunotherapy. Use of microfluidics in the study of cancer immunotherapy“.

Ignacio Ochoa is a Professor of the Department of Human Anatomy and Histology of the University of Zaragoza and researcher of the
AMB – Applied Mechanics and Bioengineering group and
NANBIOSIS U13 Tissue & Scaffold Characterization Unit from CIBER-BBN and I3A-Zaragoza University

Classes will be held on Thursday, from 4:00 p.m. to 8:00 p.m., in the CIBA Lorente de Nó Assembly Hall (with an exception that is detailed in the program) starting on 6th Feb, 2020.

It is an ongoing training course. Price: 173 €. Includes Online Access to the book “Tumor Immunology and Cancer Immunotherapy” by Amazing Books 2018

Program and registration: https://eventos.unizar.es/44697/programme/curso-de-inmunologia-tumoral-e-inmunoterapia-del-cancer.html

https://seom.org/otros-servicios/agenda/333-iv-curso-de-inmunologia-tumoral-e-inmunoterapia-del-cancer

Request pre-registration form Alberto Anel anel@unizar.es

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The University of Zaragoza, in the elite of the 500 best universities in the world

The Academic Ranking of World Universities (ARWU), known as
Shanghai Ranking, which was made public on August 15, once again places the University of Zaragoza among the elite of the 500 best universities in the world.

This indicator organizes up to 20,000 university centers worldwide. Among the keys that have been able to positively influence the results of the research, according to the Vice Chancellor for Prospect, Sustainability and Infrastructure of the University of Zaragoza, Francisco Serón, are the increase in public campus funding for four years as well as the quality of their Scientists.

The University of Zaragoza houses three of NANBIOSIS Units:

U9 Synthesis of Nanoparticles Unit, led by Jesús Santamaría and Gema Martínez

U13 Tissue & Scaffold Characterization Unit, led by Miguel Ángel Martínez Barca and Fany Peña

U27 High Performance Computing , led by Pablo Laguna

Since 2003, every August, the Academic Ranking of World Universities (ARWU), known as “Shanghai Ranking,” is published, one of the international reference studies to compare higher education institutions. The ranking selects the 1,000 best educational institutions from a global point of view, among the 20,000 higher education centers that exist.

It is possibly the most famous and most recognized university analysis that values the quality of institutions in the generation of knowledge. The research community respects the results of these rankings because they are based on objective data and their classification is reproducible.

Here you can check the results of the University of Zaragoza in this year’s Shanghai Ranking: http://www.shanghairanking.com/World-University-Rankings/University-of-Zaragoza.html.

Source:
https://www.aragondigital.es/2019/08/15/la-uz-en-la-elite-de-las-500-mejores-universidades-del-mundo-segun-el-ranking-de-shanghai/

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NANBIOSIS unit 13 participation at the VIII Conference of Young Researchers of I3A-UZ

Next Thurstday, June 6th, the “Aragón Engineering Research Institute” (I3A) of University of Zaragoza will hold the “VIII Conference of Young Researchers” at the Conference Room Building. R & D (block 1, 1st floor)

Researchers of NANBIOSIS unit U13 Tissue & Scaffold Characterization Unit will present their works

In the oral presentations section, Mohamed H. Doweidar will talk about Cell behavior under hypoxic conditions. Computational 3D model.

In the posters section in the area of ​​BIOMEDICAL ENGINEERING the researchers of unit 13 will present the following results.

Design of a microfluidics system for the simulation of the formation of atheromatous plaque. Itziar Ríos Ruiz, Sara Oliván García, Miguel Ángel Martínez Barca, Estefania Peña Baquedano.

Mechanobiological modeling of the formation of atheromatous plaque in the carotid artery of a specific patient. Patricia Hernández López, Myriam Cilla Hernández, Miguel Ángel Martínez Barca, Estefania Peña Baquedano.

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An Eskimo in the desert

An Eskimo in the desert is the title of the talk that Ignacio Ochoa Researcher of NANBIOSIS U13 Tissue & Scaffold Characterization Unit is giving today at the Pint of Science Festival in Zaragoza at 19:00.

One of the greatest advances in biomedicine was to achieve, at the end of the 19th century, maintain human cells outside the body in order to study them. This breakthrough has allowed us, for example, to discover new drugs and evaluate the toxicity of many compounds. Unfortunately, this progress has hardly evolved over these 125 years. However, the arrival of microfluidic technology has allowed us to simulate much better what actually happens in our body. This new advance will revolutionize biomedicine, bringing it closer to the goal of personalized medicine

As Iñaki has explained to NANBIOSIS “Cells are accustomed to being in a specific environment in our body (mechanical, chemical, electrical, etc.) and, when we take them out of that environment to study them in the laboratories they stop working in a similar way as they did in vivo. This change of functioning sometimes generates false positives in the study of efficacy of new drugs and generates delays and excessive costs in the development of new treatments. Thanks to the Organ on Chip technology, we can better simulate in the laboratory the environment of the cells under physiopathological conditions (rigidities, gradients, flow or the presence of different cell types) and obtain results closer to the clinic”.

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