Nanbiosis

U26. NMR: Biomedical Applications II

• Scientific Director: Prof. Ramon Martinez Máñez  rmaez@qim.upv.es
• Scientific Coordinator: Dr. Salvador Gil salvador.gil@uv.es
• Entities: Universitat de Valencia (UV)
• Address: C/Dr. Moliner, 50, Edificico Investigación, 1º Pl., 46100, Valencia, Spain
• Phone: +34 963877343
• Tel Prof. Martínez: +34 963877343 ; Tel Dr. Gil : +34 963543135
• Web: UV

U26. Sample preparation lab

U26. DRX-600 Bruker NM R equipment (14T) with autosampler

U26. DRX-600 Bruker NM R equipment (14T) with refrigerated autosampler

Description

Located in the Faculty of Medicine of the University of Valencia (UV) has a laboratory with a NMR (14T) for acquiring unique metabolic profiles of biofluids, cell lines and tissues. This Unit is coordinated by Dr. Ramón Martínez Máñez, PI of the Applied Molecular Chemistry Group of the Universidad Politécnica de Valencia, together with Dr. Salvador Gil, Director of the Central Service for Experimental Research (SCSIE).

News U26

25 Oct

Ramón Martínez Máñez, Scientific Director of NANBIOSIS U26 obtains an ERC Advanced Grant

Ramón Martínez Máñez, researcher at the Polytechnic University of Valencia (UPV) and scientific director of the Bioengineering, Biomaterials and Nanomedicine area of ​​the CIBER (CIBER-BBN) and NANBIOSIS U26, has obtained an ERC Advanced Grant –the most prestigious grant from the European Research Council– endowed with 2.5 million euros for the development of the EDISON project (Engineered Particles for Chemical Communication). This project focuses on the field of chemical or molecular communication. Its objective is the study, development and application of nanoparticles that are capable of communicating with each other and whose application would represent a revolution in the field of[...]

16 Aug

The University of Valencia among the 300 best universities in the world, hosting NANBIOSIS U26 of CIBER-BBN on RNM for Biomedical Applications

The Academic Ranking of World Universities (ARWU), known as Shanghai Ranking, which was made public on August 15, places the University of Valencia among the elite of the 300 best universities in the world and the second of the Spanish universities. This indicator organizes up to 20,000 university centers worldwide,based on transparent methodology and objective third-party data. ARWU is regarded as one of the three most influential and widely observed university rankings The NANBIOSIS U26 NMR: Biomedical Applications II created by CIBER-BBN is hosted by the University of Valencia is led by Prof. Ramón Martínez Ma´ñez and Prof Salvador Gil Grau[...]

27 Jul

1st Nanomedicine Forum of CIBER-BBN/NANBIOSIS and CSIC Nanomed Conection

During the days 30 of June and 1st of July took place in Barcelona, in the auditorium of the Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), the 1st Forum on Nanomedicine gathering scientists from the CSIC net Nanomed Conection and from the CIBER-BBN and its ICTS NANBIOSIS. This forum brought toguether researchers from the most eminent national research centers in nanomedicine, that during the two days meeting presented their works and findings and discussed the impact of nanomedicine in the fields of drug delivery, diagnosis and therapy. The workshop was open by the Director of IQAC-CSIC,  Jesús Joglar, the  Scientific Coordinator[...]

29 Mar

Is it possible to communicate microorganisms from different kingdoms? Yes, it is, using “Nanotranslators”

CIBER, March 28 2022 Researchers from the Polytechnic University of Valencia (UPV) and the CIBER-BBN has demonstrated, for the first time, the potential of using “translator” nanoparticles to facilitate communication between different types of cells or microorganisms. His study could have application in multiple fields, especially in the medical field for the prevention and treatment of cancer. “We have shown that it is possible to communicate microorganisms from different kingdoms using nanoparticles as translators. The nanoparticles process a message produced by the first type of cells (bacteria) and transform it into an understandable message for the second type of cells[...]

01 Dec

Nanomedicine in the Medicine of the Future

Scientists of CIBER-BBN and NANBIOSIS ICTS have participated in the 4th Conference “Anticipating the Medicine of the Future”, which took place on November 30th, organized by the Roche Institute Foundation. The topics for this ediction had been identified by the Observatory of Trends in the Medicine of the Future: Pharmacogenomics, Nanomedicine and Epigenomic The event counted with three roundtables for discussion in relation to the three topics. The second one, on Nanomedicine, was moderated by Joaquín Arenas, Director of the Research Institute of the 12 de Octubre University Hospital. Ramón Martínez Máñez, Professor of Inorganic Chemistry at the Interuniversity Researc[...]

27 May

New device for more efficient gluten detection

About 1% of the world’s population suffers from celiac disease, a complex and autoimmune disorder caused by ingestion of gluten and for which there is no treatment beyond its elimination from the diet. In Spain every May 27, the National Celiac Day is commemorated to publicize the disease and give visibility and support to people with celiac disease. The detection of gluten becomes a key element for celiac patients to control the disease, as well as for the food industry, whose regulation requires declaring its presence in food. In this line, a team of researchers coordinated by the professor of[...]

21 May

A new biosensor will help for the early diagnosis of breast cancer

A team of Spanish researchers coordinated by the professor of the Polytechnic University of Valencia (UPV) and scientific director of the CIBER-BBN and NANBIOSIS unit 26, Ramón Martínez Máñez, and the Valencian oncologist, co-coordinator of the Research Group of Biology in Breast Cancer of the INCLIVA Health Research Institute, of the Hospital Clínico de València, Ana Lluch, also belonging to the CIBER de Cáncer (CIBERONC), has developed a prototype of a new biosensor to help detect breast cancer in its phases earlier. The work has been published in ACS Sensors magazine. According to the latest data collected by the European[...]

20 Apr

Elena Aznar Gimeno (NANBIOSIS U26) leads a CIBER-BBN transfer project.

The CIBER-BBN transfer program, with its call for transfer projects, has selected two projects for next year with the aim of promoting the transfer of scientific or technological results, derived from the research carried out by the CIBER-BBN groups, to the industrial sector. One of these projects selected is directed by Elena Aznar Gimeno, researcher from the group led by Ramon Martínez Máñez at the IDM-Polytechnic University of Valencia, together with an external group led by Javier Pemán García, from the La Fe Health Research Institute From Valencia. The project has been jointly financed by CIBER-BBN and a company interested[...]

U28. NanoImaging Unit

• • Scientific Director: Dr. Mª Luisa García Martín mlgarcia@ibima.eu
  • Scientific Coordinator: Mónica Feijóo Cuaresma mfeijoo@ibima.eu
  • Entities: Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina (IBIMA Plataforma BIONAND)
  • Address: C/Severo Ochoa 35, 29590, Málaga, Spain
  • Phone: +34 952 367 600
  • Web: IBIMA-Plataforma BIONAND

Description

The Nanoimaging Unit is located in Malaga at the Andalusian Centre for Nanomedicine and Biotechnology (BIONAND), and it has been conceived and optimized to provide very diverse and integrated technological support for nanotechnology-based biomedical research, offering advanced services to internal and external users. This facility is coordinated by Dr Mª Luisa García Martín, who has wide expertise in the field of Magnetic Resonance Imaging and Spectroscopy applied to biomedical research.

The Unit brings together a wide range of cutting-edge technologies, and it is divided into four departments, each with a dedicated specialist:

– Small Animal Multimodal Imaging: Small animal (pre-clinical) imaging is a vital tool in biomedical research that allows biological processes and potential medicines to be studied in animal models using non-invasive methods. This department offers some of the most relevant pre-clinical imaging modalities, namely, MRI, in vivo Bioluminescence and Fluorescence Imaging, and micro-CT. These techniques are essential for preclinical evaluation and characterization of new diagnostic and therapeutic agents. The combined use of these technologies and new highly specific imaging probes are the basis of molecular imaging.

– Magnetic Resonance (NMR): it is equipped with two High-resolution NMR Spectrometers: a 400MHz NMR spectrometer for routine experiments and a higher field, 600 MHz, spectrometer dedicated to high-resolution magic angle spinning (HR-MAS) NMR and in vitro studies that are very demanding in terms of sensitivity. It also has a TD-NMR analyzer for relaxivity measurements in the clinical field (1.44 T).

– Electron Microscopy: It offers access to transmission electron microscopy (TEM), Cryo-TEM and Electron Tomography, high-resolution scanning electron microscopy (SEM) and environmental SEM. A special emphasis has been made on high-end sample preparation techniques through cryo-immobilization. All the equipment has been configured to provide its best on biological and nanomedicine applications. TEM, SEM and sample preparation facilities and services are offered to provide structural characterizations at the micro and nano scales. Biological and medical applications are the main objective of this equipment but are not limited to them. Any other scientific and engineering field can take advantage of them due to their versatility for public and private research, quality control, failure analysis, etc.

– Advanced Fluorescence: It hosts an excellent range of facilities capable of supporting high-quality biomedical research. These applications can range from the initial characterization of the fluorescent properties of novel nano-compounds to the evaluation of their medical applications using tissue culture and animal models. In addition, the range of possible applications goes far beyond nanomedicine to include the characterization of patient tissues, preclinical studies using rodent models, small-scale drug screening and studies using model organisms such as Zebrafish or Drosophila Melanogaster. The service is operated in close collaboration with the other advanced facilities of the Nanoimaging Unit, and the other units of Bionand, to ensure that researchers can easily combine fluorescence-based techniques with other complementary approaches such as Electron microscopy or Nuclear Magnetic Resonance.

Moreover, the location of the NanoImaging Unit allows it to be linked to other complementary Units available at BIONAND, such as the Cell Culture Unit (containment levels 1 and 2), the Chemical Unit (it offers a wide range of equipment and techniques in which materials and their interaction with biological samples can be characterized), the Animal House (rat, mouse and zebrafish accommodation), and the Histology Unit (it also offers Cutting/grinding based histological sectioning for hard tissues or other materials unsuitable to be sectioned by routine methods)